nm23-H1 Antibody (NM301): sc-465
- nm23-H1 Antibody (NM301) is a mouse monoclonal IgG1 κ nm23-H1 antibody, cited in 41 publications, provided at 200 µg/ml
- raised against purified nm23-H1 of human origin
- nm23-H1 Antibody (NM301) is recommended for detection of nm23-H1 of mouse, rat and human origin by IP, IF and IHC(P)
- Anti-nm23-H1 Antibody (NM301) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for nm23-H1 Antibody (NM301) for IHC(P) applications. These reagents are now offered in bundles with nm23-H1 Antibody (NM301) (see ordering information below).
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nm23-H1 Antibody (NM301) is a mouse monoclonal IgG1 kappa light chain antibody that detects the nm23-H1 protein of mouse, rat, and human origin by immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. nm23-H1 monoclonal antibody (NM301) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The nm23-H1 protein plays a crucial role as a potential suppressor of metastasis, having been identified through differential hybridization between murine melanoma sub-lines with varying metastatic capacities. Notably, highly metastatic sub-lines exhibit significantly lower levels of nm23-H1 compared to their less metastatic counterparts, highlighting its importance in cancer biology. The nm23 gene encodes a protein that is closely related to nucleotide diphosphate kinases, and in humans, the nm23-H1 and nm23-H2 proteins are homologous to two isotypes of human NDP kinases. Furthermore, nm23-H2 shares identity with PuF, a transcription factor that interacts with specific elements in the human C-Myc promoter, underscoring nm23-H2′s involvement in transcriptional regulation and potential implications in tumorigenesis.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
nm23-H1 Antibody (NM301) References:
- Molecular cloning and functional expression of the second mouse nm23/NDP kinase gene, nm23-M2. | Urano, T., et al. 1992. FEBS Lett. 309: 358-62. PMID: 1325378
- Identification of a second human nm23 gene, nm23-H2. | Stahl, JA., et al. 1991. Cancer Res. 51: 445-9. PMID: 1988104
- Functional cloning of a nucleoside diphosphate kinase from Dictyostelium discoideum. | Lacombe, ML., et al. 1990. J Biol Chem. 265: 10012-8. PMID: 2161830
- Isolation and characterization of a cDNA clone encoding rat nucleoside diphosphate kinase. | Kimura, N., et al. 1990. J Biol Chem. 265: 15744-9. PMID: 2168422
- Evidence for a novel gene associated with low tumor metastatic potential. | Steeg, PS., et al. 1988. J Natl Cancer Inst. 80: 200-4. PMID: 3346912
- Expression of nm23/NDP kinase proteins on the cell surface. | Urano, T., et al. 1993. Oncogene. 8: 1371-6. PMID: 8386830
- Human c-myc transcription factor PuF identified as nm23-H2 nucleoside diphosphate kinase, a candidate suppressor of tumor metastasis. | Postel, EH., et al. 1993. Science. 261: 478-80. PMID: 8392752
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
nm23-H1 Antibody (NM301) | sc-465 | 200 µg/ml | $322.00 | |||
nm23-H1 Antibody (NM301): m-IgG Fc BP-HRP Bundle | sc-528115 | 200 µg Ab; 10 µg BP | $361.00 | |||
nm23-H1 Antibody (NM301): m-IgGκ BP-HRP Bundle | sc-520416 | 200 µg Ab, 40 µg BP | $361.00 | |||
nm23-H1 Antibody (NM301): m-IgG1 BP-HRP Bundle | sc-542769 | 200 µg Ab; 20 µg BP | $361.00 | |||
nm23-H1 Antibody (NM301) AC | sc-465 AC | 500 µg/ml, 25% agarose | $424.00 | |||
nm23-H1 Antibody (NM301) HRP | sc-465 HRP | 200 µg/ml | $322.00 | |||
nm23-H1 Antibody (NM301) FITC | sc-465 FITC | 200 µg/ml | $336.00 | |||
nm23-H1 Antibody (NM301) PE | sc-465 PE | 200 µg/ml | $349.00 | |||
nm23-H1 Antibody (NM301) Alexa Fluor® 488 | sc-465 AF488 | 200 µg/ml | $364.00 | |||
nm23-H1 Antibody (NM301) Alexa Fluor® 546 | sc-465 AF546 | 200 µg/ml | $364.00 | |||
nm23-H1 Antibody (NM301) Alexa Fluor® 594 | sc-465 AF594 | 200 µg/ml | $364.00 | |||
nm23-H1 Antibody (NM301) Alexa Fluor® 647 | sc-465 AF647 | 200 µg/ml | $364.00 | |||
nm23-H1 Antibody (NM301) Alexa Fluor® 680 | sc-465 AF680 | 200 µg/ml | $364.00 | |||
nm23-H1 Antibody (NM301) Alexa Fluor® 790 | sc-465 AF790 | 200 µg/ml | $364.00 |