이 다클론 항체는 생산이 중단되었습니다. 권장 MLH1 (B-12) 단클론 항체(샘플 데이터 표시)를 참조하세요.
MLH1 항체 (N-20): sc-581
- MLH1 항체 N-20 는 토끼 polyclonal IgG 이며 100 µg/ml으로 제공합니다.
- human origin의 재조합MLH1를 항원으로 사용하였습니다.
- 단종된 다클론항체
DNA-mismatch repair (MMR) is an essential process in maintaining genetic stability. Lack of a functional DNA-mismatch repair pathway is a common characteristic of several different types of human cancers, either due to an MMR gene mutation or promoter methylation gene silencing. MLH1 is an integral part of the protein complex responsible for mismatch repair that is expressed in lymphocytes, heart, colon, breast, lung, spleen, testis, prostate, thyroid and gall bladder and is methylated in several ovarian tumors. Loss of MLH1 protein expression is associated with a mutated phenotype, microsatellite instability and a predisposition to cancer. In hereditary nonpolyposis colorectal cancer (HNPCC), an autosomal dominant inherited cancer syndrome that signifies a high risk of colorectal and various other types of cancer, the MLH1 gene exhibits a pathogenic mutation. Certain cancer cell lines, including leukemia CCRF-CEM, colon HCT 116 and KM12, and ovarian cancers SK-OV-3 and IGROV-1, show complete deficiency of MLH1, while MLH1 is expressed in 60% of melanomas, 70% of noninvasive squamous cell carcinomas and 30% of invasive squamous cell carcinomas.
주문정보
MLH1 (B-12): sc-271978 [ MLH1 (N-20)의 권장하는 대체 단클론항체입니다. ]
| 제품명 | 카탈로그 번호 | 단위 | 가격 | 수량 | 관심품목 | |
MLH1 항체 (B-12) | sc-271978 | 200 µg/ml | $322.00 | |||
MLH1 (B-12): m-IgG Fc BP-HRP 번들 | sc-529295 | 200 µg Ab; 10 µg BP | $361.00 | |||
MLH1 (B-12): m-IgGκ BP-HRP 번들 | sc-522112 | 200 µg Ab, 40 µg BP | $361.00 | |||
MLH1 (B-12): m-IgG1 BP-HRP 번들 | sc-543435 | 200 µg Ab; 20 µg BP | $361.00 | |||
MLH1 항체 (B-12) AC | sc-271978 AC | 500 µg/ml, 25% agarose | $424.00 | |||
MLH1 항체 (B-12) HRP | sc-271978 HRP | 200 µg/ml | $322.00 | |||
MLH1 항체 (B-12) FITC | sc-271978 FITC | 200 µg/ml | $336.00 | |||
MLH1 항체 (B-12) PE | sc-271978 PE | 200 µg/ml | $349.00 | |||
MLH1 항체 (B-12) Alexa Fluor® 488 | sc-271978 AF488 | 200 µg/ml | $364.00 | |||
MLH1 항체 (B-12) Alexa Fluor® 546 | sc-271978 AF546 | 200 µg/ml | $364.00 | |||
MLH1 항체 (B-12) Alexa Fluor® 594 | sc-271978 AF594 | 200 µg/ml | $364.00 | |||
MLH1 항체 (B-12) Alexa Fluor® 647 | sc-271978 AF647 | 200 µg/ml | $364.00 | |||
MLH1 항체 (B-12) Alexa Fluor® 680 | sc-271978 AF680 | 200 µg/ml | $364.00 | |||
MLH1 항체 (B-12) Alexa Fluor® 790 | sc-271978 AF790 | 200 µg/ml | $364.00 | |||
MLH1 (B-12) 중화펩타이드 | sc-271978 P | 100 µg/0.5 ml | $69.00 |