La/SSB Antibody (22A): sc-80655

La/SSB Antibody (22A) is a mouse monoclonal IgG1 antibody that detects La/SSB in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). La/SSB is an autoimmune RNA-binding protein that plays a crucial role in the transcription of RNA polymerase III, which is essential for synthesizing small RNAs, including tRNA and 5S rRNA. The proper functioning of La/SSB is vital for maintaining cellular homeostasis and regulating gene expression, as disruptions in La/SSB activity can lead to various autoimmune diseases, including Sjogren syndrome and systemic lupus erythematosus. La/SSB interacts with other proteins involved in RNA metabolism, such as the Ro/SSA ribonucleoprotein complex, highlighting La/SSB importance in the formation and stability of ribonucleoprotein particles. The genes encoding La/SSB and Ro/SSA are located on human chromosomes 1q31 and 11p15.5, respectively, and their expression is often correlated in autoimmune conditions, making anti-La/SSB antibody (22A) a valuable tool for studying these diseases and understanding the underlying mechanisms of autoimmunity.

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La/SSB Antibody (22A) References:

1. Unmasking the anti-La/SSB response in sera from patients with Sjogren's syndrome by specific blocking of anti-idiotypic antibodies to La/SSB antigenic determinants.  |  Routsias, JG., et al. 2002. Mol Med. 8: 293-305. PMID: 12428060
2. Cross-recognition between histones and La/SSB may account for anti-DNA reactivity in SLE patients.  |  Touloupi, E., et al. 2005. Clin Exp Immunol. 142: 172-9. PMID: 16178873
3. La/SSB ribonucleoprotein levels increased in transformed cells.  |  Rother, RP. and Thomas, PS. 1991. Clin Exp Immunol. 83: 369-74. PMID: 1848488
4. RNA recognition motif (RRM) of La/SSB: the bridge for interparticle spreading of autoimmune response to U1-RNP.  |  Routsias, JG., et al. 2010. Mol Med. 16: 19-26. PMID: 19838329
5. B-cell epitopes of the intracellular autoantigens Ro/SSA and La/SSB: tools to study the regulation of the autoimmune response.  |  Routsias, JG. and Tzioufas, AG. 2010. J Autoimmun. 35: 256-64. PMID: 20643529
6. The effect of La(SSB) on PWM-induced immunoglobulin synthesis by anti-La(SSB) positive SLE patients and healthy controls.  |  Smith, G., et al. 1987. Clin Exp Immunol. 68: 552-61. PMID: 2958189
7. Concomitant Ro/SSA and La/SSB antibodies are biomarkers for the risk of venous thromboembolism and cerebral infarction in primary Sjögren's syndrome.  |  Mofors, J., et al. 2019. J Intern Med. 286: 458-468. PMID: 31127862
8. Time-Dependent Analysis of Sicca Symptoms and Anti-Ro/SSA and Anti-La/SSB Antibodies in Patients with AQP4-IgG-Positive Neuromyelitis Optica Spectrum Disorder.  |  Akaishi, T., et al. 2023. Tohoku J Exp Med. 260: 215-221. PMID: 37081618
9. Sialylation status in placentas from anti-Ro/SSA- and anti-La/SSB-positive pregnant women.  |  Manetti, M., et al. 2024. Tissue Cell. 89: 102464. PMID: 38981186
10. The value of synthetic linear epitope analogues of La/SSB for the detection of autoantibodies to La/SSB; specificity, sensitivity and comparison of methods.  |  Yiannaki, EE., et al. 1998. Clin Exp Immunol. 112: 152-8. PMID: 9566804

The preferred La/SSB antibody is La/SSB Antibody (312B): sc-80656.