아미노 산356-500 mapping within a C-terminal cytoplasmic domain of KIR3.1 of human 의하고 기원한다
안티-KIR3.1 항체 (A-4)는 WB, IP, IF and ELISA으로 mouse, rat and human유래의 KIR3.1 를 감지하는 데에 추천한다.
IP를 위해 agarose ;WB, IHC(P) and ELISA를 위해 HRP ;또는 IF, IHC(P) and FCM를 위해 phycoerythrin or FITC 에 결합된 Anti-KIR3.1 항체 (A-4)를 제공한다.
WB (RGB), IF, IHC(P) 와FCM, RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems에 사용가능한 Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647결합제품도 있습니다.
WB (NIR), IF와FCM,Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems에 사용가능한 Alexa Fluor® 680 or Alexa Fluor® 790 결합제품도 있습니다.
m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for KIR3.1 Antibody (A-4) for WB applications. These reagents are now offered in bundles with KIR3.1 Antibody (A-4) (see ordering information below).
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KIR3.1 Antibody (A-4) is a high quality monoclonal KIR3.1 antibody (also designated GIRK1 antibody) suitable for the detection of the KIR3.1 protein of mouse, rat and human origin. KIR3.1 Antibody (A-4) is available as both the non-conjugated anti-KIR3.1 antibody form, as well as multiple conjugated forms of anti-KIR3.1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. G protein-coupled inwardly rectifying potassium channels (Kir3.1 through Kir3.4) are coupled to numerous neurotransmitter receptors in the brain and are abundantly expressed in the olfactory bulb, hippocampus, neocortex, dentate gyrus, cerebellar cortex and thalamus regions of the brain. Also known as GIRK, Kir3 potassium channels localize to the soma and dendrites as well as axons of neurons. Liberated Gbg subunits from G protein heterotrimers bind to and regulate Kir3 channel activity. Gb3- and Gb4-containing Gbg dimers bind directly to cytoplasmic domains of Kir3 proteins and increase the K+ current while Gb5-containing Gbg dimers inhibit Kir3 K+ current. Kir3 activity is also inhibited by tyrosine phosphorylation. Brain-derived neurotrophic factor activates receptor tyrosine kinase B, which then phosphorylates Kir3 tyrosine residues, effectively inactivating the Kir3 channels.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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