Molecular structure of IWR-1-exo, CAS Number: 1127442-87-8
IWR-1-exo (CAS 1127442-87-8)
See product citations (2)
Application:
IWR-1-exo is an inhibitor of the Wnt/β-catenin pathway
CAS Number:
1127442-87-8
Purity:
≥98%
Molecular Weight:
409.44
Molecular Formula:
C25H19N3O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
IWR-1-exo is a diastereomer of IWR-1-endo (sc-295215) which is the active inhibitor of the Wnt signaling pathway. IWR-1-endo displays an IC50 = 180 nM, which inhibits the Wnt/beta-catenin pathway reporter. These studies suggest that IWR-1-exo is an ideal negative control in these tests because it has little effect on the Wnt pathway at 10muM compared its active form, IWR-1-endo. The Wnt signaling pathway is an important cascade involved in homeostasis, embryonic development, and tumorigenesis. Currently, IWR-1-exo along with its active form, are essential in cancer research, as it is believed that the Wnt pathway is a main target to inhibiting several cancers.
IWR-1-exo (CAS 1127442-87-8) References
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- Factors controlling the rhythmic contraction of collagen gels by neonatal heart cells. | Souren, JE., et al. 1992. In Vitro Cell Dev Biol. 28A: 199-204. PMID: 1582995
- Wnt/beta-catenin signaling in development and disease. | Clevers, H. 2006. Cell. 127: 469-80. PMID: 17081971
- Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. | Chen, B., et al. 2009. Nat Chem Biol. 5: 100-7. PMID: 19125156
- Structure-activity relationship studies of small-molecule inhibitors of Wnt response. | Lu, J., et al. 2009. Bioorg Med Chem Lett. 19: 3825-7. PMID: 19410457
- Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. | Huang, SM., et al. 2009. Nature. 461: 614-20. PMID: 19759537
- Drugging the cancer stem cell compartment: lessons learned from the hedgehog and Wnt signal transduction pathways. | Dodge, ME. and Lum, L. 2011. Annu Rev Pharmacol Toxicol. 51: 289-310. PMID: 20887197
- Small molecule Wnt inhibitors enhance the efficiency of BMP-4-directed cardiac differentiation of human pluripotent stem cells. | Ren, Y., et al. 2011. J Mol Cell Cardiol. 51: 280-7. PMID: 21569778
- Tissue factor induces VEGF expression via activation of the Wnt/β-catenin signaling pathway in ARPE-19 cells. | Wang, Y., et al. 2016. Mol Vis. 22: 886-97. PMID: 27499609
- Wnt and Shh signals regulate neural stem cell proliferation and differentiation in the optic tectum of adult zebrafish. | Shitasako, S., et al. 2017. Dev Neurobiol. 77: 1206-1220. PMID: 28589698
- TAZ is required for lung alveolar epithelial cell differentiation after injury. | Sun, T., et al. 2019. JCI Insight. 5: PMID: 31211697
- PARsylated transcription factor EB (TFEB) regulates the expression of a subset of Wnt target genes by forming a complex with β-catenin-TCF/LEF1. | Kim, S., et al. 2021. Cell Death Differ. 28: 2555-2570. PMID: 33753903
- Zebrafish twist2/dermo1 regulates scale shape and scale organization during skin development and regeneration. | Jacob, T., et al. 2021. Cells Dev. 166: 203684. PMID: 33994357
- Finding a Needle in a Haystack. Identification of Tankyrase, a Novel Therapeutic Target of the Wnt Pathway Using Chemical Genetics | Atwood K. Cheung, Feng Cong. 2014. Concepts and Case Studies in Chemical Biology.
Inhibitor of:
beta-catenin, and Wnt.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IWR-1-exo, 5 mg | sc-295216 | 5 mg | $77.00 | |||
IWR-1-exo, 10 mg | sc-295216A | 10 mg | $121.00 |