Molecular structure of iCRT 14, CAS Number: 677331-12-3
iCRT 14 (CAS 677331-12-3)
See product citations (9)
Alternate Names:
5-[[2,5-Dimethyl-1-(3-pyridinyl)-1H -pyrrol-3-yl]methylene]-3-phenyl-2,4-thiazolidined ion
Application:
iCRT 14 is a potent β-catenin-responsive transcription (CRT) inhibitor
CAS Number:
677331-12-3
Purity:
≥98%
Molecular Weight:
375.44
Molecular Formula:
C21H17N3O2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
iCRT 14 is a potent inhibitor of beta-catenin-responsive transcription (CRT) (IC50 = 40.3 nM in assays of Wnt pathway activity). The Wnt pathway is a cell signaling system involved in regulating cell fate, proliferation, migration, and organogenesis during embryonic development. iCRT 14 influences the interaction between β-catenin and TCF4. β-catenin is a key mediator in Wnt signaling; upon Wnt activation, stabilized β-catenin translocates to the nucleus, where it forms a complex with TCF and other co-factors to activate the transcription of Wnt target genes. By blocking the β-catenin/TCF interaction, iCRT 14 effectively inhibits the transcriptional activation of Wnt target genes, thereby modulating the pathway′s activity.
iCRT 14 (CAS 677331-12-3) References
- Acute Wnt pathway activation positively regulates leptin gene expression in mature adipocytes. | Chen, ZL., et al. 2015. Cell Signal. 27: 587-97. PMID: 25550093
- β-Catenin acts in a position-independent regeneration response in the simple eumetazoan Hydra. | Gufler, S., et al. 2018. Dev Biol. 433: 310-323. PMID: 29108673
- Regulation of influenza virus replication by Wnt/β-catenin signaling. | More, S., et al. 2018. PLoS One. 13: e0191010. PMID: 29324866
- Insights into intestinal regeneration signaling mechanisms. | Bello, SA., et al. 2020. Dev Biol. 458: 12-31. PMID: 31605680
- Blockade of β-Catenin-Induced CCL28 Suppresses Gastric Cancer Progression via Inhibition of Treg Cell Infiltration. | Ji, L., et al. 2020. Cancer Res. 80: 2004-2016. PMID: 32156780
- β-Catenin inhibition shapes tumor immunity and synergizes with immunotherapy in colorectal cancer. | Wang, C., et al. 2020. Oncoimmunology. 9: 1809947. PMID: 32939327
- Blockers of Wnt3a, Wnt10a, or β-Catenin Prevent Chemotherapy-Induced Neuropathic Pain In Vivo. | Kim, HK., et al. 2021. Neurotherapeutics. 18: 601-614. PMID: 33128175
- Therapeutic effects of blocking β-catenin against hepatocellular carcinoma-induced activation of inflammation, fibrosis and tumor invasion. | Hassan, HM., et al. 2021. Biomed Pharmacother. 135: 111216. PMID: 33433352
- Enhancement of transgene expression by the β-catenin inhibitor iCRT14. | Spivack, K., et al. 2021. Plasmid. 114: 102556. PMID: 33472046
- Wnt antagonists suppress herpes simplex virus type 1 productive infection. | Harrison, KS. and Jones, C. 2021. Antiviral Res. 191: 105082. PMID: 33961904
- Regulation of Avian Leukosis Virus Subgroup J Replication by Wnt/β-Catenin Signaling Pathway. | Qiao, D., et al. 2021. Viruses. 13: PMID: 34696398
- Inhibition of Wnt-β-Catenin Signaling by ICRT14 Drug Depends of Post-Transcriptional Regulation by HOTAIR in Human Cervical Cancer HeLa Cells. | Trujano-Camacho, S., et al. 2021. Front Oncol. 11: 729228. PMID: 34778043
- β-Catenin-Specific Inhibitor, iCRT14, Promotes BoHV-1 Infection-Induced DNA Damage in Human A549 Lung Adenocarcinoma Cells by Enhancing Viral Protein Expression. | Ding, X., et al. 2022. Int J Mol Sci. 23: PMID: 35216447
- The canonical Wnt/β-catenin signaling pathway facilitates pseudorabies virus proliferation and enhances virus-induced autophagy. | Wang, C., et al. 2022. Vet Microbiol. 272: 109502. PMID: 35841697
- Pro-inflammatory role of Wnt/β-catenin signaling in endothelial dysfunction. | Wadey, KS., et al. 2022. Front Cardiovasc Med. 9: 1059124. PMID: 36794234
Inhibitor of:
beta-catenin, Pygopus 2, and Wnt-5b.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
iCRT 14, 10 mg | sc-362746 | 10 mg | $189.00 | |||
| US: Only available in the US | ||||||
iCRT 14, 50 mg | sc-362746A | 50 mg | $771.00 | |||
| US: Only available in the US | ||||||