안티-HuR 항체 3A2 는 마우스 monoclonal IgG1 κ HuR 항체, 439간행물에 인용, 이며 200 µg/ml으로 제공합니다.
full length HuR of human 의하고 제작된다
HuR 항체 (3A2)는 WB, IP, IF, IHC(P) and ELISA으로mouse, rat, human and Xenopus유래의 HuR, HuB, HuC and HuD 를 감지하는 데에 추천한다
IP를 위해 agarose ;WB, IHC(P) and ELISA를 위해 HRP ;또는 IF, IHC(P) and FCM를 위해 phycoerythrin or FITC 에 결합된 Anti-HuR 항체 (3A2)를 제공한다.
WB (RGB), IF, IHC(P) 와FCM, RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems에 사용가능한 Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647결합제품도 있습니다.
WB (NIR), IF와FCM,Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems에 사용가능한 Alexa Fluor® 680 or Alexa Fluor® 790 결합제품도 있습니다.
m-IgGκ BP-HRP (mouse IgGκ binding protein-HRP) is the preferred detection reagent for HuR Antibody (3A2) for WB and IHC(P) applications. This reagent is now offered in a bundle with HuR Antibody (3A2) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
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Labware ships FedEx Ground free of charge to the contiguous US
HuR Antibody (3A2) is a high quality monoclonal HuR antibody (also designated ELAV like RNA binding protein 4 antibody or ELAVL4 antibody) suitable for the detection of the HuR protein of mouse, rat, human and Xenopus laevis origin. HuR Antibody (3A2) is available as both the non-conjugated anti-HuR antibody form, as well as multiple conjugated forms of anti-HuR antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The Elav-like genes encode for a family of RNA-binding proteins. Elav, a Drosophila protein and the first described member, is expressed immediately after neuroblastic differentiation into neurons and is necessary for neuronal differentiation and maintenance. Several mammalian Elav-like proteins, designated HuB (also designated Hel-N1 in human, or Mel-N1 in mouse), HuC and HuD are also expressed in postmitotic neurons. An additional mammalian homolog, HuR, which is also designated HuA, is ubiquitously expressed and is also overexpressed in a wide variety of tumors. Characteristically, these homologs all contain three RNA recognition motifs (RRM) and they specifically bind to AU-rich elements (ARE) in the 3′-untranslated region of mRNAs transcripts. ARE sites target mRNA for rapid degradation and thereby regulate the expression levels of genes involved in cell growth and differentiation. When Elav-like proteins associate with these ARE sites this degradation is inhibited, leading to an increased stability of the corresponding transcript. Elav proteins function within the nucleus, and they are shuttled between the nucleus and cytoplasm by a nuclear export signal, which is a regulatory feature of the Elav-like proteins as it limits their accessibility to ARE sites.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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