HSV-1/2 gB Antibody (H126): sc-69799

HSV-1/2 gB Antibody (H126) is a mouse monoclonal IgG2b antibody that detects glycoprotein B (gB) of HSV-1 and HSV-2 by western blotting (WB) and immunofluorescence (IF). Anti-HSV-1/2 gB antibody (H126) plays a critical role in understanding the mechanisms of viral entry and infection, as glycoprotein B is essential for the fusion of the viral envelope with the host cell membrane, a process vital for the viral lifecycle. HSV-1/2 gB (H126) monoclonal antibody enables research on gB protein, which exists as a homodimer crucial for proper conformational changes necessary for membrane fusion. The extracellular domain of HSV-1 gB spans amino acids 31-730, while the cytoplasmic domain includes amino acids 796-904, and similar structural features are observed in HSV-2 gB. The importance of gB in viral growth is underscored by the fact that gB-deficient virions can bind to host cells but fail to initiate the synthesis of virus-specific proteins, highlighting its role in the early stages of infection. Anti-HSV-1/2 gB antibody (H126) enables valuable insights into viral entry mechanisms and potential therapeutic interventions targeting these critical glycoproteins.

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HSV-1/2 gB Antibody (H126) References:

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2. Effect of immunization with herpes simplex virus type-1 (HSV-1) glycoprotein D (gD) plus the immune enhancer GPI-0100 on infection with HSV-1 or HSV-2.  |  Quenelle, DC., et al. 2006. Vaccine. 24: 1515-22. PMID: 16288820
3. Herpes simplex virus type 2 (HSV-2) establishes latent infection in a different population of ganglionic neurons than HSV-1: role of latency-associated transcripts.  |  Margolis, TP., et al. 2007. J Virol. 81: 1872-8. PMID: 17151134
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5. Failure of intertypic recombinant constructed from HSV-1 x HSV-2 virulent parents to induce ocular pathology.  |  Lausch, RN., et al. 1987. Curr Eye Res. 6: 27-32. PMID: 3030649
6. Differences in the morphology of herpes simplex virus infected cells. II. Type specific membrane alterations of HSV-1 and HSV-2 infected cells.  |  Hampl, H., et al. 1981. Med Microbiol Immunol. 169: 209-23. PMID: 6265748
7. The 140-kDa RR1 protein from both HSV-1 and HSV-2 contains an intrinsic protein kinase activity capable of autophosphorylation but it is transphosphorylation defective.  |  Ali, MA. 1995. Virology. 207: 409-16. PMID: 7886945
8. Flow cytometric indirect immunofluorescence assay with high sensitivity and specificity for the detection of antibodies to HSV-1 and HSV-2.  |  Caruso, A., et al. 1993. Eur J Epidemiol. 9: 547-52. PMID: 8307141
9. Mutational analysis of the virion host shutoff gene (UL41) of herpes simplex virus (HSV): characterization of HSV type 1 (HSV-1)/HSV-2 chimeras.  |  Everly, DN. and Read, GS. 1997. J Virol. 71: 7157-66. PMID: 9311788
10. Characterization of T cell responses to herpes simplex virus type 1 (HSV-1) and herpes simplex virus type 2 (HSV-2) using a TNF-beta ELISpot cytokine assay.  |  Schmid, DS., et al. 1997. Arch Virol. 142: 1659-71. PMID: 9672626

The preferred HSV-1/2 gB antibody is HSV-1/2 gB Antibody (10B7): sc-56987.