HPA1 Antibody (A-7): sc-518150

HPA1 Antibody (A-7) is a mouse monoclonal IgG3 antibody that detects heparanase 1 (HPA1) in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). HPA1 plays a critical role in the degradation of heparan sulfate side chains of heparan sulfate proteoglycans in the extracellular matrix, which is essential for various physiological and pathological processes, including tumor metastasis and inflammation. By dismantling the subendothelial basal membrane, HPA1 facilitates the extravasation of blood-borne tumor cells and inflammatory leukocytes, thereby promoting cancer progression and angiogenesis. HPA1′s ability to release growth factors and cytokines upon degradation further stimulates cell proliferation and chemotaxis, highlighting HPA1′s importance in tumor vascularization and the inflammatory response. Additionally, fibroblasts can endocytose extracellular HPA1, leading to HPA1 accumulation in the cytoplasm, which may influence cellular signaling pathways. The gene encoding human HPA1 is located on chromosome 4q21.3, underscoring HPA1′s significance in human health and disease. Anti-HPA1 antibody (A-7) is an invaluable tool for researchers investigating the roles of heparanase in cancer biology and inflammation.

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HPA1 Antibody (A-7) References:

1. Rapid genotyping of human platelet antigen 1 (HPA-1) with fluorophore-labelled hybridization probes on the LightCycler.  |  Nauck, MS., et al. 1999. Br J Haematol. 105: 803-10. PMID: 10354151
2. An international trial demonstrates suitability of a newly developed whole-blood ELISA kit for multicentre platelet HPA-1 phenotyping.  |  Bessos, H., et al. 1999. Vox Sang. 77: 103-6. PMID: 10516555
3. Gene frequencies of the HPA-1 to 6 and Gov human platelet antigens in Thai blood donors.  |  Kupatawintu, P., et al. 2005. Immunohematology. 21: 5-9. PMID: 15783299
4. Platelet receptor HPA-1 polymorphism of alphaIIbbeta3 and 807 C/T polymorphism of alpha2beta1 and Buerger's disease.  |  Ostojic, L., et al. 2007. Angiology. 58: 169-74. PMID: 17495265
5. Immunologic and structural analysis of eight novel domain-deletion beta3 integrin peptides designed for detection of HPA-1 antibodies.  |  Stafford, P., et al. 2008. J Thromb Haemost. 6: 366-75. PMID: 18045240
6. Polymorphisms of the human platelet alloantigens HPA-1, HPA-2, HPA-3, and HPA-4 in ischemic stroke.  |  Saidi, S., et al. 2008. Am J Hematol. 83: 570-3. PMID: 18383324
7. Platelet glycoprotein IIb/IIIa (HPA-1 and HPA-3) polymorphisms in patients with hemorrhagic fever with renal syndrome.  |  Liu, Z., et al. 2009. Hum Immunol. 70: 452-6. PMID: 19286442
8. Polymorphisms of human platelet alloantigens HPA-1 and HPA-2 associated with severe coronary artery disease.  |  Abboud, N., et al. 2010. Cardiovasc Pathol. 19: 302-7. PMID: 19515580
9. Human platelet alloantigens HPA-1, HPA-2, and HPA-3 polymorphisms associated with extent of severe coronary artery disease.  |  Abboud, N., et al. 2010. J Thromb Thrombolysis. 29: 409-15. PMID: 19562259
10. Detection of human platelets antigen polymorphism (HPA-1 and HPA-3) and human factor XIII mutation in Sudanese women with recurrent pregnancy loss.  |  Babker, AM., et al. 2024. BMC Res Notes. 17: 66. PMID: 38443929

The preferred HPA1 antibody is HPA1 Antibody (D-3): sc-518151.