frizzled-2 Antibody (K19R): sc-74019

frizzled-2 Antibody (K19R) is a rat monoclonal IgG2a antibody that detects frizzled-2 protein of mouse origin by western blotting (WB) and immunoprecipitation (IP). anti-frizzled-2 antibody (K19R) is available as the non-conjugated format. frizzled-2 protein plays a crucial role in the Wnt signaling pathway, which is essential for various developmental processes, including cell proliferation, differentiation, and tissue polarity. frizzled-2 protein is primarily located in the cell membrane, where frizzled-2 functions as a receptor for Wnt ligands, initiating intracellular signaling cascades that influence gene expression and cellular behavior. frizzled-2 presence in tissues such as the fetal kidney and lung, as well as in the adult ovary and colon, underscores frizzled-2′s importance in both developmental and adult physiological processes. frizzled-2 protein is involved in mediating the Wnt/cGMP/Ca2+ pathway, which is critical for calcium signaling in cells. Angiotensin II regulation of frizzled-2 expression highlights frizzled-2′s potential role in cardiovascular and renal physiology. Through Wnt protein binding, frizzled-2 activates stored calcium release, thereby influencing various downstream signaling pathways, including NFAT-dependent transcription and phosphatidylinositol pathway activation. This multifaceted role of frizzled-2 in cellular signaling and development makes frizzled-2 protein a significant target for research in developmental biology and related fields.

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frizzled-2 Antibody (K19R) References:

1. Frizzleds: new members of the superfamily of G-protein-coupled receptors.  |  Malbon, CC. 2004. Front Biosci. 9: 1048-58. PMID: 14977528
2. Angiotensin II modulates frizzled-2 receptor expression in rat vascular smooth muscle cells.  |  Castoldi, G., et al. 2005. Clin Sci (Lond). 108: 523-30. PMID: 15667337
3. SFRP1 regulates the growth of retinal ganglion cell axons through the Fz2 receptor.  |  Rodriguez, J., et al. 2005. Nat Neurosci. 8: 1301-9. PMID: 16172602
4. Gene expression profile of quiescent and activated rat hepatic stellate cells implicates Wnt signaling pathway in activation.  |  Jiang, F., et al. 2006. J Hepatol. 45: 401-9. PMID: 16780995
5. Suppression of cyclic GMP-dependent protein kinase is essential to the Wnt/cGMP/Ca2+ pathway.  |  Ma, L. and Wang, HY. 2006. J Biol Chem. 281: 30990-1001. PMID: 16920709
6. Gene expression analysis in human osteoblasts exposed to dexamethasone identifies altered developmental pathways as putative drivers of osteoporosis.  |  Hurson, CJ., et al. 2007. BMC Musculoskelet Disord. 8: 12. PMID: 17295923
7. Different Wnt signals act through the Frizzled and RYK receptors during Drosophila salivary gland migration.  |  Harris, KE. and Beckendorf, SK. 2007. Development. 134: 2017-25. PMID: 17507403
8. Frizzled 2 and frizzled 7 function redundantly in convergent extension and closure of the ventricular septum and palate: evidence for a network of interacting genes.  |  Yu, H., et al. 2012. Development. 139: 4383-94. PMID: 23095888
9. Frizzled-2 small interfering RNA protects hepatic BRL-3A cells against Hypoxia / Reoxygenation via modulation of autophagy.  |  Hu, X., et al. 2020. Turk J Gastroenterol. 31: 167-179. PMID: 32141827
10. Successful therapeutic intervention in new mouse models of frizzled 2-associated congenital malformations.  |  Liegel, RP., et al. 2023. Development. 150: PMID: 36789910
11. A human homologue of the Drosophila polarity gene frizzled has been identified and mapped to 17q21.1.  |  Zhao, Z., et al. 1995. Genomics. 27: 370-3. PMID: 7558010
12. Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7.  |  Sagara, N., et al. 1998. Biochem Biophys Res Commun. 252: 117-22. PMID: 9813155

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-frizzled-2 Antibody (K19R) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-frizzled-2 Antibody (K19R) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

frizzled-2 Antibody (K19R) Specifications

Alternate Product Name: frizzled-2

Product Clone Name: K19R

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a

Amino Acids:

Epitope Target: frizzled-2

Epitope Species: mouse

Product Reactivity/Detection: frizzled-2

Species Reactivity/Detection: mouse

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG_2a in 1.0 ml of PBS with < 0.1% sodium azide and protein stabilizer

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for frizzled-2 Antibody (K19R): N/A

The preferred frizzled antibody is frizzled Antibody (1C11): sc-13559.