D-myo-Inositol-1,2,3,6-tetraphosphate, sodium salt MF: C6H12O18P4•4Na
MW: 588.00
A small, soluble second messenger.

D-myo-Inositol-1,2,3,6-tetraphosphate, sodium salt

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Alternate Names: 1,2,3,6-IP4 (sodium salt); Ins(1,2,3,6)-P4 (sodium salt)
Application D-myo-Inositol-1,2,3,6-tetraphosphate, sodium salt is a small, soluble second messenger
분자량: 588.00
분자식: C6H12O18P44Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

D-myo-Inositol-1,2,3,6-tetraphosphate, sodium salt is one of the many inositol phosphate (InsP) isomers that act as small, soluble second messengers in the transmission of cellular signals. The most studied InsP, Ins(1,4,5)-P3 is a second messenger produced in cells by phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositol-4,5-biphosphate. Binding of Ins(1,4,5)-P3 to its receptor on the endoplasmic reticulum causes opening of the calcium channels and an increase in intracellular calcium. Ins(1,2,3,6)-P3 is less potent than Ins(1,4,5)-P3 at initiating Ca2+ release when injected into Xenopus oocytes.


References

1 Berridge, M.J. Inositol trisphosphate and calcium signalling. Nature 361 315-325 (1993). 2 Majerus, P.W. Inositol phosphate biochemistry. Annu Rev Biochem 61 225-250 (1992). 3 Shears, S.B. The versatility of inositol phosphates as cellular signals. Biochim Biophys Acta 1436 49-67 (1998). 4 Streb, H., Irvine, R.F., Berridge, M.J., et al. Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate. Nature 306 67-69 (1983).

Appearance :
Lyophilized powder
Physical State :
Solid
저장 :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
57347477
SMILES :
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