CREB3L3 Antibody (E-5): sc-377363
- CREB3L3 Antibody (E-5) is a mouse monoclonal IgG2a (lambda light chain) provided at 200 µg/ml
- raised against amino acids 90-237 mapping within an internal region of CREB3L3 of human origin
- recommended for detection of CREB3L3 of human origin by WB, IP, IF and ELISA
- TransCruz reagent for ChIP application (sc-377363 X, 200 µg/0.1 ml)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CREB3L3 Antibody (E-5). This work is in progress.
QUICK LINKS
CREB3L3 Antibody (E-5) is a mouse monoclonal IgG2a antibody that detects CREB3L3 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CREB3L3, also known as cAMP-responsive element-binding protein 3-like protein 3 or HYST1481, is a 461 amino acid single-pass type II membrane protein primarily localized to the endoplasmic reticulum (ER). CREB3L3 undergoes cleavage during ER stress and translocates to the nucleus to function as a transcription factor. In this capacity, CREB3L3 activates genes involved in the unfolded protein response and the acute phase response, both vital for cellular homeostasis and stress management. CREB3L3 shows reduced expression in hepatocellular carcinoma, suggesting a potential tumor suppressor role. CREB3L3 operates as a dimer and features a leucine zipper domain, a KDEL-like sequence, and a bZIP domain, which are essential for DNA binding capabilities. Alternative splicing results in three distinct isoforms of CREB3L3, further diversifying functional roles in cellular processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CREB3L3 Antibody (E-5) References:
- Tunicamycin negatively regulates BMP2-induced osteoblast differentiation through CREBH expression in MC3T3E1 cells. | Jang, WG., et al. 2011. BMB Rep. 44: 735-40. PMID: 22118540
- Transcriptional regulation of apolipoprotein A-IV by the transcription factor CREBH. | Xu, X., et al. 2014. J Lipid Res. 55: 850-9. PMID: 24598141
- Novel CREB3L3 Nonsense Mutation in a Family With Dominant Hypertriglyceridemia. | Cefalù, AB., et al. 2015. Arterioscler Thromb Vasc Biol. 35: 2694-9. PMID: 26427795
- A novel EWS-CREB3L3 gene fusion in a mesenteric sclerosing epithelioid fibrosarcoma. | Dewaele, B., et al. 2017. Genes Chromosomes Cancer. 56: 695-699. PMID: 28569045
- HRD1-ERAD controls production of the hepatokine FGF21 through CREBH polyubiquitination. | Wei, J., et al. 2018. EMBO J. 37: PMID: 30389664
- Synergistic regulation of hepatic Fsp27b expression by HNF4α and CREBH. | Kasano-Camones, CI., et al. 2020. Biochem Biophys Res Commun. 530: 432-439. PMID: 32553626
- Loss-of-Function CREB3L3 Variants in Patients With Severe Hypertriglyceridemia. | Dron, JS., et al. 2020. Arterioscler Thromb Vasc Biol. 40: 1935-1941. PMID: 32580631
- N-glycosylation of CREBH improves lipid metabolism and attenuates lipotoxicity in NAFLD by modulating PPARα and SCD-1. | Zhang, N., et al. 2020. FASEB J. 34: 15338-15363. PMID: 32996649
- The transcription factors CREBH, PPARa, and FOXO1 as critical hepatic mediators of diet-induced metabolic dysregulation. | Yang, Z., et al. 2021. J Nutr Biochem. 95: 108633. PMID: 33789150
- Adipose expression of CREB3L3 modulates body weight during obesity. | McCann, MA., et al. 2021. Sci Rep. 11: 19400. PMID: 34588527
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CREB3L3 Antibody (E-5) | sc-377363 | 200 µg/ml | $322.00 | |||
CREB3L3 Antibody (E-5) X | sc-377363 X | 200 µg/0.1 ml | $322.00 |