CPEB Antibody (E-10): sc-137146
- CPEB Antibody (E-10) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 1-300 mapping at the N-terminus of CPEB of human origin
- recommended for detection of CPEB long and short isoforms of human origin by WB, IP, IF and ELISA
- TransCruz reagent for ChIP application (sc-137146 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for CPEB Antibody (E-10) for WB applications. These reagents are now offered in bundles with CPEB Antibody (E-10) (see ordering information below).
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SEE ALSO...
CPEB Antibody (E-10) is a mouse monoclonal IgG1 antibody that detects CPEB in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CPEB, or cytoplasmic polyadenylation element binding protein, plays a crucial role in the regulation of messenger RNA translation, which is vital for various cellular processes including cell-cycle progression and early development. CPEB (E-10) antibody targets a protein predominantly located in the cytoplasm, where CPEB binds to specific RNA sequences known as cytoplasmic polyadenylation elements, thereby influencing mRNA stability and localization. Anti-CPEB antibody (E-10) enables research into essential functions during oocyte maturation, as CPEB modulates translational activation and repression of critical mRNAs during this process. CPEB is synthesized during oogenesis and stored in oocytes, with degradation occurring via the proteasome pathway, often involving ubiquitin-conjugated intermediates. CPEB′s ability to regulate translation through these mechanisms underscores its importance in developmental biology and neurobiology, making anti-CPEB antibody (E-10) a valuable research tool.
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CPEB Antibody (E-10) References:
- XGef mediates early CPEB phosphorylation during Xenopus oocyte meiotic maturation. | Martínez, SE., et al. 2005. Mol Biol Cell. 16: 1152-64. PMID: 15635100
- CPEB regulation of human cellular senescence, energy metabolism, and p53 mRNA translation. | Burns, DM. and Richter, JD. 2008. Genes Dev. 22: 3449-60. PMID: 19141477
- The nuclear experience of CPEB: implications for RNA processing and translational control. | Lin, CL., et al. 2010. RNA. 16: 338-48. PMID: 20040591
- CPEB and two poly(A) polymerases control miR-122 stability and p53 mRNA translation. | Burns, DM., et al. 2011. Nature. 473: 105-8. PMID: 21478871
- CPEB control of NF-kappaB nuclear localization and interleukin-6 production mediates cellular senescence. | Groppo, R. and Richter, JD. 2011. Mol Cell Biol. 31: 2707-14. PMID: 21536657
- CPEB-mediated ZO-1 mRNA localization is required for epithelial tight-junction assembly and cell polarity. | Nagaoka, K., et al. 2012. Nat Commun. 3: 675. PMID: 22334078
- The CPEB-family of proteins, translational control in senescence and cancer. | Fernández-Miranda, G. and Méndez, R. 2012. Ageing Res Rev. 11: 460-72. PMID: 22542725
- CPEB alteration and aberrant transcriptome-polyadenylation lead to a treatable SLC19A3 deficiency in Huntington's disease. | Picó, S., et al. 2021. Sci Transl Med. 13: eabe7104. PMID: 34586830
- CPEB and translational control by cytoplasmic polyadenylation: impact on synaptic plasticity, learning, and memory. | Huang, YS., et al. 2023. Mol Psychiatry. 28: 2728-2736. PMID: 37131078
- A Combinatorial Code for CPEB-Mediated c-myc Repression. | Ogami, K., et al. 2023. Cells. 12: PMID: 37830624
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CPEB Antibody (E-10) | sc-137146 | 200 µg/ml | $322.00 | |||
CPEB Antibody (E-10): m-IgG Fc BP-HRP Bundle | sc-539946 | 200 µg Ab; 10 µg BP | $361.00 | |||
CPEB Antibody (E-10): m-IgG1 BP-HRP Bundle | sc-541805 | 200 µg Ab; 20 µg BP | $361.00 | |||
CPEB Antibody (E-10) X | sc-137146 X | 200 µg/0.1 ml | $322.00 |