CLIC6 Antibody (E-11): sc-365303
- CLIC6 Antibody (E-11) is a mouse monoclonal IgG2a κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 163-195 within an internal region of CLIC6 of mouse origin
- Anti-CLIC6 Antibody (E-11) is recommended for detection of CLIC6 of mouse and rat origin by WB, IP, IF and ELISA
- Anti-CLIC6 Antibody (E-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for CLIC6 Antibody (E-11) for WB applications. These reagents are now offered in bundles with CLIC6 Antibody (E-11) (see ordering information below).
CLIC6 Antibody (E-11) is a mouse monoclonal IgG2a kappa light chain antibody that detects CLIC6 in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CLIC6 (E-11) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Chloride intracellular channel 6 (CLIC6) is a probable chloride ion channel that plays a vital role in water-secreting cells by regulating chloride ion transport, which is crucial for maintaining cellular homeostasis and fluid balance. CLIC6 is distinguished from other members of the chloride channel family by its unique structure; CLIC6 is significantly longer and features a GC-rich segment that encodes a 10-amino-acid motif repeated 14 times at the amino-terminus. This structural complexity indicates specialized functions and interactions within the cell. CLIC6 gene exemplifies large-scale segmental paralogy, with a substantial segment on human chromosome 21 being triplicated on chromosomes 1 and 6. CLIC6 is primarily localized in the cytoplasm but translocates to the plasma membrane upon chloride ion efflux, highlighting a dynamic role in cellular signaling. CLIC6 is expressed in various tissues, including the brain, placenta, pancreas, and liver, and has been shown to interact with dopamine receptors DRD2, DRD3, and DRD4, further underscoring importance in neurotransmission and cellular communication. CLIC6 is a 704-amino-acid protein with two known isoforms, A and B, and is also referred to as parchorin in rabbit models.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CLIC6 Antibody (E-11) References:
- The DNA sequence of human chromosome 21. | Hattori, M., et al. 2000. Nature. 405: 311-9. PMID: 10830953
- Intracellular potassium and chloride channels: an update. | Debska, G., et al. 2001. Acta Biochim Pol. 48: 137-44. PMID: 11440163
- Segmental paralogy in the human genome: a large-scale triplication on 1p, 6p, and 21q. | Strippoli, P., et al. 2002. Mamm Genome. 13: 456-62. PMID: 12226712
- Challenging accepted ion channel biology: p64 and the CLIC family of putative intracellular anion channel proteins (Review). | Ashley, RH. 2003. Mol Membr Biol. 20: 1-11. PMID: 12745921
- CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors. | Griffon, N., et al. 2003. Brain Res Mol Brain Res. 117: 47-57. PMID: 14499480
- Identification of a novel member of the CLIC family, CLIC6, mapping to 21q22.12. | Friedli, M., et al. 2003. Gene. 320: 31-40. PMID: 14597386
- [Comparative proteomics research of apoptosis initiation induced by homoharringtonine in HL-60 cells]. | Chen, CY., et al. 2003. Zhonghua Xue Ye Xue Za Zhi. 24: 624-8. PMID: 14761608
- Mapping functional domains of chloride intracellular channel (CLIC) proteins in vivo. | Berry, KL. and Hobert, O. 2006. J Mol Biol. 359: 1316-33. PMID: 16737711
- The gastric H,K ATPase as a drug target: past, present, and future. | Sachs, G., et al. 2007. J Clin Gastroenterol. 41 Suppl 2: S226-42. PMID: 17575528
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CLIC6 Antibody (E-11) | sc-365303 | 200 µg/ml | $322.00 | |||
CLIC6 Antibody (E-11): m-IgG Fc BP-HRP Bundle | sc-525873 | 200 µg Ab; 10 µg BP | $361.00 | |||
CLIC6 Antibody (E-11): m-IgG2a BP-HRP Bundle | sc-546449 | 200 µg Ab; 10 µg BP | $361.00 | |||
CLIC6 Antibody (E-11) AC | sc-365303 AC | 500 µg/ml, 25% agarose | $424.00 | |||
CLIC6 Antibody (E-11) HRP | sc-365303 HRP | 200 µg/ml | $322.00 | |||
CLIC6 Antibody (E-11) FITC | sc-365303 FITC | 200 µg/ml | $336.00 | |||
CLIC6 Antibody (E-11) PE | sc-365303 PE | 200 µg/ml | $349.00 | |||
CLIC6 Antibody (E-11) Alexa Fluor® 488 | sc-365303 AF488 | 200 µg/ml | $364.00 | |||
CLIC6 Antibody (E-11) Alexa Fluor® 546 | sc-365303 AF546 | 200 µg/ml | $364.00 | |||
CLIC6 Antibody (E-11) Alexa Fluor® 594 | sc-365303 AF594 | 200 µg/ml | $364.00 | |||
CLIC6 Antibody (E-11) Alexa Fluor® 647 | sc-365303 AF647 | 200 µg/ml | $364.00 | |||
CLIC6 Antibody (E-11) Alexa Fluor® 680 | sc-365303 AF680 | 200 µg/ml | $364.00 | |||
CLIC6 Antibody (E-11) Alexa Fluor® 790 | sc-365303 AF790 | 200 µg/ml | $364.00 | |||
CLIC6 (E-11) Neutralizing Peptide | sc-365303 P | 100 µg/0.5 ml | $69.00 |