CAP1 Antibody (D-9): sc-376512

CAP1 Antibody (D-9) is a mouse monoclonal IgG2a antibody that detects cyclase-associated protein 1 (CAP1) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CAP1 plays a crucial role in the regulation of actin filaments, which are essential for maintaining cell shape, motility, and intracellular transport. By mediating processes such as the establishment of cell polarity and mRNA localization, CAP1 is vital for proper cellular function and organization. CAP1′s localization to the cell membrane allows effective interaction with the actin cytoskeleton, influencing various signaling pathways critical for cell growth and differentiation. CAP1 expression throughout the body highlights CAP1′s importance in diverse physiological processes. Anti-CAP1 antibody (D-9) serves as an invaluable tool for researchers studying the dynamics of the actin cytoskeleton and its implications in health and disease, including potential links to cancer progression.

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CAP1 Antibody (D-9) References:

1. High expression and prognostic role of CAP1 and CtBP2 in breast carcinoma: associated with E-cadherin and cell proliferation.  |  Liu, X., et al. 2014. Med Oncol. 31: 878. PMID: 24522810
2. Phosphorylation of the cytoskeletal protein CAP1 controls its association with cofilin and actin.  |  Zhou, GL., et al. 2014. J Cell Sci. 127: 5052-65. PMID: 25315833
3. CAP1 is overexpressed in human epithelial ovarian cancer and promotes cell proliferation.  |  Hua, M., et al. 2015. Int J Mol Med. 35: 941-9. PMID: 25652936
4. Overexpression of CAP1 and its significance in tumor cell proliferation, migration and invasion in glioma.  |  Fan, YC., et al. 2016. Oncol Rep. 36: 1619-25. PMID: 27432289
5. Association of RETN and CAP1 SNPs, Expression and Serum Resistin Levels with Breast Cancer in Mexican Women.  |  Muñoz-Palomeque, A., et al. 2018. Genet Test Mol Biomarkers. 22: 209-217. PMID: 29641286
6. The Cytoskeletal Protein Cyclase-Associated Protein 1 (CAP1) in Breast Cancer: Context-Dependent Roles in Both the Invasiveness and Proliferation of Cancer Cells and Underlying Cell Signals.  |  Hasan, R. and Zhou, GL. 2019. Int J Mol Sci. 20: PMID: 31151140
7. Effects of tumor-specific CAP1 expression and body constitution on clinical outcomes in patients with early breast cancer.  |  Bergqvist, M., et al. 2020. Breast Cancer Res. 22: 67. PMID: 32560703
8. Novel role of CAP1 in regulation RNA polymerase II-mediated transcription elongation depends on its actin-depolymerization activity in nucleoplasm.  |  Zhang, Q., et al. 2021. Oncogene. 40: 3492-3509. PMID: 33911205
9. Role of serum CAP1 protein in the diagnosis of patients with first-time acute myocardial infarction.  |  Jin, D., et al. 2023. Medicine (Baltimore). 102: e34700. PMID: 37773847
10. CPNE7 Regulates Amyloidogenesis Through CAP1-Dependent ADAM10 Translation.  |  Yang, J., et al. 2025. J Neurochem. 169: e70026. PMID: 40026213

The preferred CAP1 antibody is CAP1 Antibody (E-4): sc-376191.