Bax Antibody (6D150): sc-70408

Bax Antibody (6D150) is a mouse monoclonal IgG1 antibody that detects Bax in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Bax is a critical pro-apoptotic protein that plays a vital role in the regulation of apoptosis, or programmed cell death, which is essential for maintaining cellular homeostasis and eliminating damaged or unwanted cells. The balance between Bax and its anti-apoptotic counterpart, Bcl-2, is crucial in determining cell fate; while Bax promotes apoptosis, Bcl-2 inhibits it, thus influencing various physiological processes and responses to stress. Bax is primarily localized to the outer mitochondrial membrane, where Bax facilitates the release of cytochrome c and other pro-apoptotic factors from the mitochondria into the cytosol, triggering the apoptotic cascade. The interaction between Bax and Bcl-2 is particularly significant, as Bax can form heterodimers with Bcl-2, effectively neutralizing its protective effects and promoting cell death in response to apoptotic signals. Understanding the dynamics of Bax and its interactions is essential for elucidating the mechanisms of apoptosis and developing therapeutic strategies for diseases characterized by dysregulated cell death, such as cancer. Anti-Bax antibody (6D150) provides a reliable tool for researchers investigating these critical pathways in various biological contexts.

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Bax Antibody (6D150) References:

1. Bax translocation to mitochondria subsequent to a rapid loss of mitochondrial membrane potential.  |  Smaili, SS., et al. 2001. Cell Death Differ. 8: 909-20. PMID: 11526446
2. Bax and Bak independently promote cytochrome C release from mitochondria.  |  Degenhardt, K., et al. 2002. J Biol Chem. 277: 14127-34. PMID: 11836241
3. Bax-induced cell death of Arabidopsis is meditated through reactive oxygen-dependent and -independent processes.  |  Baek, D., et al. 2004. Plant Mol Biol. 56: 15-27. PMID: 15604726
4. Bax targeting to mitochondria occurs via both tail anchor-dependent and -independent mechanisms.  |  Valentijn, AJ., et al. 2008. Cell Death Differ. 15: 1243-54. PMID: 18437166
5. Bax mRNA therapy using cationic liposomes for human malignant melanoma.  |  Okumura, K., et al. 2008. J Gene Med. 10: 910-7. PMID: 18563851
6. Bax activates endophilin B1 oligomerization and lipid membrane vesiculation.  |  Rostovtseva, TK., et al. 2009. J Biol Chem. 284: 34390-9. PMID: 19805544
7. Human VAMP3 Suppresses or Negatively Regulates Bax Induced Apoptosis in Yeast.  |  Akintade, DD. and Chaudhuri, B. 2021. Biomedicines. 9: PMID: 33478086
8. Bax- and Bak-induced cell death in the fission yeast Schizosaccharomyces pombe.  |  Jürgensmeier, JM., et al. 1997. Mol Biol Cell. 8: 325-39. PMID: 9190211
9. Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations.  |  Hsu, YT. and Youle, RJ. 1998. J Biol Chem. 273: 10777-83. PMID: 9553144
10. bax, but not bcl-2, influences the prognosis of human pancreatic cancer.  |  Friess, H., et al. 1998. Gut. 43: 414-21. PMID: 9863489

The preferred Bax antibody is Bax Antibody (B-9): sc-7480.