APEH Antibody (B-2): sc-393452

APEH Antibody (B-2) is a mouse monoclonal IgG2a antibody that detects APEH in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). APEH, also known as Acyl-peptide hydrolase, is a 732 amino acid cytoplasmic protein that functions as a homotetramer, playing a crucial role in the hydrolysis of N-terminal acetylated amino acids from small acetylated peptides. This enzymatic activity facilitates the subsequent processing of the acetyl amino acid by aminoacylases, leading to the production of acetate and free amino acids, which are vital for various metabolic processes. The gene encoding human APEH is located on chromosome 3, a region often deleted in several cancers, including renal cell carcinoma and small cell lung carcinoma, indicating a potential role for APEH in tumorigenesis. Chromosome 3 is notable for its extensive genetic content, housing over 1,100 genes, including key tumor suppressor genes such as RASSF1, which mediates apoptosis, HYAL1, which regulates cell migration, and SEMA3B, an angiogenesis suppressor. APEH (B-2) antibody is an essential tool for researchers investigating the implications of APEH in cancer biology and metabolic regulation.

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APEH Antibody (B-2) References:

1. Identification of valproic acid glucuronide hydrolase as a key enzyme for the interaction of valproic acid with carbapenem antibiotics.  |  Suzuki, E., et al. 2010. Drug Metab Dispos. 38: 1538-44. PMID: 20551238
2. Is there a genetic cause for cancer cachexia? - a clinical validation study in 1797 patients.  |  Solheim, TS., et al. 2011. Br J Cancer. 105: 1244-51. PMID: 21934689
3. Small peptide inhibitors of acetyl-peptide hydrolase having an uncommon mechanism of inhibition and a stable bent conformation.  |  Sandomenico, A., et al. 2012. J Med Chem. 55: 2102-11. PMID: 22309188
4. Genetic and microbial factors modulating the ubiquitin proteasome system in inflammatory bowel disease.  |  Cleynen, I., et al. 2014. Gut. 63: 1265-74. PMID: 24092863
5. Treatment of cognitive dysfunction in major depressive disorder--a review of the preclinical evidence for efficacy of selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors and the multimodal-acting antidepressant vortioxetine.  |  Pehrson, AL., et al. 2015. Eur J Pharmacol. 753: 19-31. PMID: 25107284
6. Adaptive response activated by dietary cis9, trans11 conjugated linoleic acid prevents distinct signs of gliadin-induced enteropathy in mice.  |  Bergamo, P., et al. 2016. Eur J Nutr. 55: 729-740. PMID: 25840667
7. Observation of Clinically Relevant Drug Interaction in Chimeric Mice with Humanized Livers: The Case of Valproic Acid and Carbapenem Antibiotics.  |  Suzuki, E., et al. 2017. Eur J Drug Metab Pharmacokinet. 42: 965-972. PMID: 28447323
8. Intratracheal Transplantation of Amnion-Derived Mesenchymal Stem Cells Ameliorates Hyperoxia-Induced Neonatal Hyperoxic Lung Injury via Aminoacyl-Peptide Hydrolase.  |  Li, Z., et al. 2020. Int J Stem Cells. 13: 221-236. PMID: 32323511
9. PBPK modelling for the evaluation of drug-drug interaction between meropenem and valproic acid.  |  Liu, H., et al. 2024. Br J Clin Pharmacol.. PMID: 39578702
10. Shared genetic architecture of type 2 diabetes with muscle mass and function and frailty reveals comorbidity etiology and pleiotropic druggable targets.  |  Dou, C., et al. 2025. Metabolism. 164: 156112. PMID: 39710002

The preferred APEH antibody is APEH Antibody (G-6): sc-376612.