ADH8 Antibody (B-10): sc-390552

ADH8 Antibody (B-10) is a mouse monoclonal IgG2a antibody that detects ADH8 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). ADH8, also known as ADHFE1 or HOT, is a 467 amino acid protein that plays a crucial role in the metabolism of gamma-hydroxybutyrate, converting it into succinic semialdehyde, which is subsequently transformed into succinic acid for energy production in the Krebs cycle. This enzymatic activity is vital for maintaining metabolic balance and energy homeostasis, particularly in the liver where ADH8 is predominantly expressed. ADH8 is localized in the mitochondrion, an essential site for energy production and metabolic processes, highlighting ADH8′s importance in cellular respiration and energy metabolism. Notably, ADH8 exists in four isoforms due to alternative splicing, which may contribute to ADH8′s functional diversity and regulatory mechanisms within metabolic pathways. Anti-ADH8 antibody (B-10) is an invaluable tool for researchers studying metabolic disorders, liver function, and the intricate pathways involving alcohol dehydrogenases.

The preferred ADH8 antibody is ADH8 Antibody (F-9): sc-390387.