7-Hydroxyaristolochic acid A is an aristolochic acid. These compounds are the active ingredients, responsible for the hepatoxicity and renal toxicity, found in Aristolochic fangchi. They form DNA adducts in renal tissue and are associated with urothelial carcinoma formation.
1. Pfau, W., et al., 1990. 32P-postlabelling analysis of the DNA adducts formed by aristolochic acid I and II. Carcinogenesis. 11(9): 1627-33. PMID: 2401053
2. Rossiello, M R., et al., 1993. Induction of hepatic nodules in the rat by aristolochic acid. Cancer letters. 71(1-3): 83-7. PMID: 8364902
3. Mengs, U., et al., 1993. Renal toxicity of aristolochic acid in rats as an example of nephrotoxicity testing in routine toxicology. Archives of toxicology. 67(5): 307-11. PMID: 8368940
4. Hadjiolov, D., et al., 1993. Effect of diallyl sulfide on aristolochic acid-induced forestomach carcinogenesis in rats. Carcinogenesis. 14(3): 407-10. PMID: 8453716
5. Schmeiser, H H., et al., 1996. Detection of DNA adducts formed by aristolochic acid in renal tissue from patients with Chinese herbs nephropathy. Cancer research. 56(9): 2025-8. PMID: 8616845
6. Levi, M., et al., 1998. Acute hepatitis in a patient using a Chinese herbal tea--a case report. Pharmacy world & science : PWS. 20(1): 43-4. PMID: 9536471
7. Nortier, J L., et al., 2000. Urothelial carcinoma associated with the use of a Chinese herb (Aristolochia fangchi) The New England journal of medicine. 342(23): 1686-92. PMID: 10841870
산타크루즈바이오테크놀러지는 생물의학연구에 필요한 제품을 개발하는 선구자입니다. Toll Free 1-800-457-3801로 연락주세요. Copyright © 2007-2021 Santa Cruz Biotechnology, Inc. 판권소유. "Santa Cruz Biotechnology", 와 Santa Cruz Biotechnology, Inc. 로고, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", 및 San Juan Ranch 로고, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz"와 "EZ Touch" 는 Santa Cruz Biotechnology, Inc의 등록된 상표입니다. 모든 상표는 각자 소유주의 소유입니다.