20S Proteasome α7 Antibody (GH6): sc-100456
- 20S Proteasome α7 Antibody (GH6) is a mouse monoclonal IgG2b κ, cited in 7 publications, provided at 100 µg/ml
- raised against recombinant 20S Proteasome α7 of human origin
- recommended for detection of 20S Proteasome α7 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for 20S Proteasome α7 Antibody (GH6). This work is in progress.
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20S Proteasome α7 Antibody (GH6) is a mouse monoclonal IgG2b antibody that detects 20S Proteasome α7 in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). 20S Proteasome α7 plays a crucial role in the proteasome complex, which maintains cellular homeostasis by degrading misfolded, damaged, or unneeded proteins. This process regulates various cellular functions, including cell cycle, signal transduction, and response to oxidative stress. The 20S core particle, where 20S Proteasome α7 resides, is composed of a cylindrical structure housing catalytic β subunits responsible for proteolytic activity. 20S Proteasome α7 contributes to structural integrity and proper functioning of the proteasome, ensuring efficient and selective degradation. Anti-20S Proteasome α7 antibody (GH6) enables researchers to gain insights into protein turnover dynamics and proteasome function in various physiological and pathological conditions, making this antibody an invaluable tool for cell biology and disease research.
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LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
20S Proteasome α7 Antibody (GH6) References:
- Genetic variants associated with myocardial infarction in the PSMA6 gene and Chr9p21 are also associated with ischaemic stroke. | Heckman, MG., et al. 2013. Eur J Neurol. 20: 300-8. PMID: 22882272
- Quantitative assessment of the influence of PSMA6 variant (rs1048990) on coronary artery disease risk. | Wang, H., et al. 2013. Mol Biol Rep. 40: 1035-41. PMID: 23111455
- Juvenile idiopathic arthritis subtype- and sex-specific associations with genetic variants in the PSMA6/PSMC6/PSMA3 gene cluster. | Sjakste, T., et al. 2014. Pediatr Neonatol. 55: 393-403. PMID: 24875235
- 1,4-Dihydropyridine derivatives without Ca2+-antagonist activity up-regulate Psma6 mRNA expression in kidneys of intact and diabetic rats. | Ošiņa, K., et al. 2016. Cell Biochem Funct. 34: 3-6. PMID: 26634809
- Disassembly of the self-assembled, double-ring structure of proteasome α7 homo-tetradecamer by α6. | Ishii, K., et al. 2015. Sci Rep. 5: 18167. PMID: 26657688
- Genetic variations in the PSMA3, PSMA6 and PSMC6 genes are associated with type 1 diabetes in Latvians and with expression level of number of UPS-related and T1DM-susceptible genes in HapMap individuals. | Sjakste, T., et al. 2016. Mol Genet Genomics. 291: 891-903. PMID: 26661414
- Genetic association between inflammatory genes (IL-1α, CD14, LGALS2, PSMA6) and risk of ischemic stroke: A meta-analysis. | Misra, S., et al. 2016. Meta Gene. 8: 21-9. PMID: 27014587
- Association between functional variant of inflammatory system gene (PSMA6) and end-stage kidney disease. | Buraczynska, M., et al. 2016. Int Urol Nephrol. 48: 2083-2087. PMID: 27671905
- Structural Fluctuations of the Human Proteasome α7 Homo-Tetradecamer Double Ring Imply the Proteasomal α-Ring Assembly Mechanism. | Song, C., et al. 2021. Int J Mol Sci. 22: PMID: 33926037
- The Genetic Variants of NOTCH3 (6746T>C) and PSMA6 (-8C>G) as Possible Risk Factors of Psoriasis Development. | Bartosińska, J., et al. 2021. Life (Basel). 11: PMID: 34575036
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
20S Proteasome α7 Antibody (GH6) | sc-100456 | 100 µg/ml | $339.00 |