Date published: 2026-5-31

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2-Methylpyrrolidine (CAS 765-38-8)

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CAS Number:
765-38-8
Molecular Weight:
85.15
Molecular Formula:
C5H11N
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2-Methylpyrrolidine is an aliphatic heterocyclic compound featuring a five-membered ring structure. Its significance in scientific research lies in its multifunctionality as a synthetic intermediate and its involvement in the synthesis of diverse natural products. Moreover, 2-Methylpyrrolidine has been identified as an inhibitor of specific enzymes, including cyclooxygenase-2 (COX-2).


2-Methylpyrrolidine (CAS 765-38-8) References

  1. Efficient and practical synthesis of (R)-2-methylpyrrolidine.  |  Zhao, D., et al. 2006. J Org Chem. 71: 4336-8. PMID: 16709084
  2. Modeling proline ligation in the heme-dependent CO sensor, CooA, using small-molecule analogs.  |  Pinkert, JC., et al. 2006. J Biol Inorg Chem. 11: 642-50. PMID: 16724227
  3. In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: trends across multiple chemical series.  |  Nersesian, DL., et al. 2008. Bioorg Med Chem Lett. 18: 355-9. PMID: 18077160
  4. [Regioselectivity in the dehydrogenation of substituted ethylenediamines as nicotine models].  |  Möhrle, H. and Berlitz, J. 2009. Pharmazie. 64: 565-73. PMID: 19827296
  5. Extraction of Teucrium manghuaense and evaluation of the bioactivity of its extract.  |  Yin, G., et al. 2009. Int J Mol Sci. 10: 4330-41. PMID: 20057948
  6. Asymmetric synthesis of chiral cyclic amine from cyclic imine by bacterial whole-cell catalyst of enantioselective imine reductase.  |  Mitsukura, K., et al. 2010. Org Biomol Chem. 8: 4533-5. PMID: 20820664
  7. Purification and characterization of a novel (R)-imine reductase from Streptomyces sp. GF3587.  |  Mitsukura, K., et al. 2011. Biosci Biotechnol Biochem. 75: 1778-82. PMID: 21897027
  8. Structure and activity of NADPH-dependent reductase Q1EQE0 from Streptomyces kanamyceticus, which catalyses the R-selective reduction of an imine substrate.  |  Rodríguez-Mata, M., et al. 2013. Chembiochem. 14: 1372-9. PMID: 23813853
  9. 2-Methyl-4-(naphthalen-2-yl)-3a-nitro-3,3a,4,9b-tetra-hydro-2H-spiro-[chromeno[3,4-c]pyrrole-1,3'-indolin]-2'-one.  |  Devi, SK., et al. 2013. Acta Crystallogr Sect E Struct Rep Online. 69: o1045-6. PMID: 24046621
  10. Structure, Activity and Stereoselectivity of NADPH-Dependent Oxidoreductases Catalysing the S-Selective Reduction of the Imine Substrate 2-Methylpyrroline.  |  Man, H., et al. 2015. Chembiochem. 16: 1052-9. PMID: 25809902
  11. Polymorphic chiral squaraine crystallites in textured thin films.  |  Zablocki, J., et al. 2020. Chirality. 32: 619-631. PMID: 32155676
  12. Optical Activity in Saturated Cyclic Amines: Untangling the Roles of Nitrogen-Inversion and Ring-Puckering Dynamics.  |  Craft, CL., et al. 2021. J Phys Chem A. 125: 5562-5584. PMID: 34142836
  13. Acylative kinetic resolution of racemic methyl-substituted cyclic alkylamines with 2,5-dioxopyrrolidin-1-yl (R)-2-phenoxypropanoate.  |  Gruzdev, DA., et al. 2022. Org Biomol Chem. 20: 862-869. PMID: 35006228
  14. Synthesis of Chiral Covalent Organic Frameworks via Asymmetric Organocatalysis for Heterogeneous Asymmetric Catalysis.  |  Li, F., et al. 2022. Angew Chem Int Ed Engl. 61: e202115044. PMID: 35357070

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-Methylpyrrolidine, 2 g

sc-230564
2 g
$166.00