Z-Asp-2,6-dichlorobenzoyloxymethylketone CAS: 153088-73-4
MF: C20H17Cl2NO7
MW: 454.3
A broad Caspase Inhibitor.

Z-Asp-2,6-dichlorobenzoyloxymethylketone (CAS 153088-73-4)

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Z-Asp-2,6-dichlorobenzoyloxymethylketone is rated 5.0 out of 5 by 1.
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別名: Caspase-1 Inhibitor V
アプリケーション: Z-Asp-2,6-dichlorobenzoyloxymethylketone is a broad Caspase Inhibitor
CAS 番号: 153088-73-4
Purity: >98%
Molecular Weight: 454.3
Molecular Formula: C20H17Cl2NO7
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
* Refer to Certificate of Analysis for lot specific data (including water content).
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Z-Asp-2,6-dichlorobenzoyloxymethylketone (Z-Asp-CH2-DCB), a cell permeable broad Caspase Inhibitor, prevents development of severe pulmonary hypertension and intravascular pulmonary endothelial cell growth caused by chronic hypoxia in murine models. This compound has also been shown to prevent des-ring B colchicine induced apoptosis of cells. Evaluation of Z-Asp-CH2-DCB on caspase inhibition has shown a reduced rate of cleavage of Troponin I-C, an important component of cardiac contractile apparatus. Z-Asp-2,6-dichlorobenzoyloxymethylketone is an inhibitor of caspase-3 and caspase-6.


参考文献

1. Gajate, C., et al. 2000. Cancer Res. 60: 2651-2659. PMID: 10825137
2. Taraseviciene-Stewart, L., et al. 2001. FASEB J. 15: 427-438. PMID: 11156958
3. Chandrashekhar, Y., et al. 2004. J. Am. Coll. Cardiol. 43: 295-301. PMID: 14736452

Physical State :
Solid
Solubility :
Soluble in DMSO (5 mg/ml), and methanol (50 mg/ml). Insoluble in water.
保存方法 :
Store at -20° C
Melting Point :
233.45° C (Predicted)
Boiling Point :
674.22° C at 760 mmHg (Predicted)
Density :
1.44 g/cm3 (Predicted)
Refractive Index :
n20D 1.59 (Predicted)
IC50 :
Caspase-3: IC50 = 1.1 µM; Caspase-6: IC50 = 4.1 µM
pK Values :
pKa: 4.01 (Predicted)
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD00674885
SMILES :
C1=CC=C(C=C1)COC(=O)NC(CC(=O)O)C(=O)COC(=O)C2=C(C=CC=C2Cl)Cl

Download SDS (MSDS)

分析表

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