SCYL3 Antibody (E-7): sc-398106

SCYL3 Antibody (E-7) is a mouse monoclonal IgG1 antibody that detects SCYL3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SCYL3, also known as Protein-associating with the carboxyl-terminal domain of ezrin, is a 742 amino acid protein that plays a crucial role in cellular signaling and cytoskeletal organization. SCYL3 is characterized by a unique structure, which includes an N-terminal myristoylation consensus sequence, a protein kinase domain, two HEAT motifs, and a C-terminal ezrin-binding domain. These structural features facilitate SCYL3′s interaction with other proteins, such as Ezrin and actin, which are essential for maintaining cell shape and motility. SCYL3 undergoes phosphorylation, a post-translational modification that can influence activity and interactions within the cell. Ubiquitously expressed, SCYL3 is localized in lamellipodia, where SCYL3 colocalizes with HCAM, underscoring importance in dynamic cellular processes. The SCYL3 gene, which contains 14 exons and exists in two alternatively spliced isoforms, is conserved across various species, including chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, and mosquito, and is mapped to human chromosome 1q24.2. With versatile applications and critical role in cellular dynamics, anti-SCYL3 antibody (E-7) serves as an invaluable tool for researchers studying the intricate mechanisms of cell signaling and structure.

The preferred SCYL3 antibody is SCYL3 Antibody (G-8): sc-398328.