SAP 97 Antibody (D-9): sc-514478

SAP 97 Antibody (D-9) is a mouse monoclonal IgG2a antibody that detects SAP 97 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SAP 97, also known as hdlg-1 in humans and NE-dlg in neuronal and endocrine tissues, is a member of the MAGUK (membrane-associated guanylate kinase homolog) protein family, which plays a crucial role in maintaining synaptic structures and facilitating intracellular signaling. SAP 97 is primarily localized at the membrane-cytoskeleton interface, where SAP 97 interacts with various signaling molecules and cytoskeletal components, thereby influencing synaptic plasticity and cellular communication. The structural features of SAP 97, including distinct protein domains, allow SAP 97 to engage in protein-protein interactions vital for growth and development regulation, particularly in neuronal and endocrine systems. SAP 97′s interaction with the tumor suppressor protein APC highlights SAP 97′s potential role in growth regulation and cancer biology, making SAP 97 an important target for research in both neurobiology and oncology. Anti-SAP 97 antibody (D-9) is an essential tool for researchers exploring the functional dynamics of SAP 97 in various biological contexts.

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SAP 97 Antibody (D-9) References:

1. Dlg1 Maintains Dendritic Cell Function by Securing Voltage-Gated K+ Channel Integrity.  |  Dong, X., et al. 2019. J Immunol. 202: 3187-3197. PMID: 31028120
2. Scrib and Dlg1 polarity proteins regulate Ag presentation in human dendritic cells.  |  Barreda, D., et al. 2020. J Leukoc Biol. 108: 883-893. PMID: 32293058
3. LncRNA DLG1-AS1 Promotes Cancer Cell Proliferation in Triple Negative Breast Cancer by Downregulating miR-203.  |  Li, S. 2020. J Breast Cancer. 23: 343-354. PMID: 32908786
4. The DLG1-AS1/miR-497/YAP1 axis regulates papillary thyroid cancer progression.  |  Huang, Y., et al. 2020. Aging (Albany NY). 12: 23326-23336. PMID: 33197895
5. DLG1-AS1 is activated by MYC and drives the proliferation and migration of hepatocellular carcinoma cells through miR-497-5p/SSRP1 axis.  |  Min, J., et al. 2021. Cancer Cell Int. 21: 16. PMID: 33407499
6. The SF3B1R625H mutation promotes prolactinoma tumor progression through aberrant splicing of DLG1.  |  Guo, J., et al. 2022. J Exp Clin Cancer Res. 41: 26. PMID: 35039052
7. lncRNA DLG1-AS1 promotes cervical cancer cell gemcitabine resistance by regulating miR-16-5p/HDGF.  |  Zou, MJ., et al. 2022. J Obstet Gynaecol Res. 48: 1836-1847. PMID: 35388952
8. DLG1 promotes the antiviral innate immune response by inhibiting p62-mediated autophagic degradation of IKKε.  |  Chang, H., et al. 2023. J Virol. 97: e0150123. PMID: 37982618
9. NONO promotes gallbladder cancer cell proliferation by enhancing oncogenic RNA splicing of DLG1 through interaction with IGF2BP3/RBM14.  |  Yang, ZY., et al. 2024. Cancer Lett. 587: 216703. PMID: 38341127
10. KDM5B promotes SMAD4 loss-driven drug resistance through activating DLG1/YAP to induce lipid accumulation in pancreatic ductal adenocarcinoma.  |  Wang, Y., et al. 2024. Cell Death Discov. 10: 252. PMID: 38789418

The preferred SAP 97 antibody is SAP 97 Antibody (2D11): sc-9961.