Molecular structure of PGE1 (Prostaglandin E1), CAS Number: 745-65-3
PGE1 (Prostaglandin E1) (CAS 745-65-3)
See product citations (16)
Alternate Names:
PGE1 (Prostaglandin E1) also known as Alprostadil; Edex; Caverject; Muse; Prostin VR; alprostadil Prostaglandin E1; (11alpha,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-enoic acid; lprostadil; Befar; Caverject
Application:
PGE1 (Prostaglandin E1) is a major prostaglandin that affects protein kinase C (PKC), calcium movement, and adenylate cyclase
CAS Number:
745-65-3
Purity:
≥97%
Molecular Weight:
354.48
Molecular Formula:
C20H34O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
PGE1 (Prostaglandin E1) is a major prostaglandin found in human semen that acts as an inhibitor of platelet aggregation. Additionally, PGE1 may act to affect protein kinase C (PKC), calcium movement, and adenylate cyclase, yielding a multitude of physiological effects. Adenylate cyclase is an enzyme responsible for the conversion of ATP to cyclic AMP (cAMP). Elevated levels of cAMP within cells lead to a variety of cellular responses, including the inhibition of platelet aggregation. The cAMP pathway is pivotal for transmitting signals from the cell surface to its interior, influencing processes such as cell growth, differentiation, and apoptosis. PGE1 is the cyclooxygenase metabolite of dihomo-y-linolenic acid, but it is undetectable in the plasma of animals.
PGE1 (Prostaglandin E1) (CAS 745-65-3) References
- Mouse peritoneal macrophage prostaglandin E1 synthesis is altered by dietary gamma-linolenic acid. | Fan, YY. and Chapkin, RS. 1992. J Nutr. 122: 1600-6. PMID: 1322453
- Improved transdermal delivery of prostaglandin E1 through hairless mouse skin: combined use of carboxymethyl-ethyl-beta-cyclodextrin and penetration enhancers. | Uekama, K., et al. 1992. J Pharm Pharmacol. 44: 119-21. PMID: 1352811
- Multiple hormone actions: the rises in cAMP and Ca++ in MDCK-cells treated with glucagon and prostaglandin E1 are independent processes. | Kurstjens, NP., et al. 1990. Biochem Biophys Res Commun. 167: 1162-9. PMID: 1690994
- Regulation of agonist-induced prostaglandin E1 versus prostaglandin E2 production. A mass analysis. | Rubin, D. and Laposata, M. 1991. J Biol Chem. 266: 23618-23. PMID: 1748640
- How do poly lactide-co-glycolide microspheres for prostaglandin E1 operate in ischemic tissue? Local sustained release of prostaglandin E1 induces neovascularization in murine hindlimb ischemia. | Okazaki, T. and Aoyagi, S. 2009. Circ J. 73: 1201-2. PMID: 19556701
- Prostaglandin E1-mediated, cyclic AMP-independent, down-regulation of Gs alpha in neuroblastoma x glioma hybrid cells. | McKenzie, FR. and Milligan, G. 1990. J Biol Chem. 265: 17084-93. PMID: 2170366
- Prostaglandin E1: a review. | Kirtland, SJ. 1988. Prostaglandins Leukot Essent Fatty Acids. 32: 165-74. PMID: 2901111
- Prostaglandin E1 Inhibits GLI2 Amplification-Associated Activation of the Hedgehog Pathway and Drug Refractory Tumor Growth. | Wu, F., et al. 2020. Cancer Res. 80: 2818-2832. PMID: 32371475
- Inhibitory effects of prostaglandin E1 on T-cell mediated cytotoxicity against isolated mouse liver cells. | Ogawa, M., et al. 1988. Gastroenterology. 94: 1024-30. PMID: 3257931
- Prostaglandin E1 attenuates AngII-induced cardiac hypertrophy via EP3 receptor activation and Netrin-1upregulation. | Shen, Y., et al. 2021. J Mol Cell Cardiol. 159: 91-104. PMID: 34147480
- The Role of Prostaglandin E1 as a Pain Mediator through Facilitation of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 2 via the EP2 Receptor in Trigeminal Ganglion Neurons of Mice. | Kwon, J., et al. 2021. Int J Mol Sci. 22: PMID: 34948328
- Prostaglandins in reproductive physiology. | Speroff, L. and Ramwell, PW. 1970. Am J Obstet Gynecol. 107: 1111-30. PMID: 4914185
- Relationship between chemical structure and platelet-aggregation activity of prostaglandins. | Kloeze, J. 1969. Biochim Biophys Acta. 187: 285-92. PMID: 4981666
- Prostaglandin E1 and E2 in bovine semen: quantification by gas chromatography. | Mai, J. and Kinsella, JE. 1980. Prostaglandins. 20: 187-97. PMID: 7413990
- Cell cycle related inhibition of mouse vascular smooth muscle cell proliferation by prostaglandin E1: relationship between prostaglandin E1 and intracellular cAMP levels. | Fan, YY., et al. 1996. Prostaglandins Leukot Essent Fatty Acids. 54: 101-7. PMID: 8848428
Inhibitor of:
cAMP, CD42c, GPR83, HMW-Guanylin, and VASP.Activator of:
1190002N15Rik, 2410002O22Rik, 3830406C13Rik, 4930549C01Rik, ABHD8, ADAL, AKAP 220, Ang-1, ANKRD47, ARA160, ARHGAP20, ARHGAP4, ARHGAP9, ARRDC2, Bcy1, Bordetella pertussis toxin subunit S1, BRAK, c-GMP, C19orf60, CASC1, CatSper, CatSper3, CCDC120, CCDC153, CCDC35, CCDC82, CCDC85B, CCDC94, Cdc35, CLDND2, connexin 31, CPB, CREBL2, CUL-4A, dHAND, DP, DP2_CRTH2, Duffy, DUS3L, E130203B14Rik, EP1, EPCR, Factor XIII A, FOXP1, G β1, Gα i-1, Gγ 5, GC kinase, GDE6, GPATCH1, GPR-152, GPR-44, GPR179, GPR3, GPR63, GRK 1, H2-Q1, HICE1, Integrin αIIb, Integrin αL, IQCE, IZUMO1, KPL2, LOC342918, LOC388564, LR8, LRP5L, LRRC50, Ly-55A, MBD3L5, MBNL1, METT5D1, MIPU1, MOBKL2A, MPND, Nim1, Nlk, NOL8, NPS, NUDT3, Odf3, OR5B12, OTTMUSG00000013284, OVCH1, P117, PAAF1, PAPL, PDE 3A, Peptide YY3, PGF2alphaR, PHACTR2, PHT2, PIR1, PKAβ cat, PKAγ, Platelet IIb, PLEKHH2, PLET-1, PR3, PRR18, PRR9, RBMY1E, RENBP, RGS1, RGS5, RGS6, RIMBP3C, RSHL1, RTP4, SerpinA11, Skint9, SLM-1, smoothelin, SPRYD5, SSTR3, TCP-10b, Tdpoz2, Tdpoz3, Tdpoz5, Tect1, TEX16, TEX19.2, TEX22, TFIIIC220, THEG, TLR11, TMEM132A, TMEM136, TMEM216, TTC9C, VHX, VMAC, Vmn2r10, Vmn2r101, Vmn2r103, Vmn2r106, Vmn2r108, Vmn2r110, Vmn2r112, Vmn2r114, Vmn2r116, Vmn2r118, Vmn2r123, Vmn2r24, Vmn2r35, Vmn2r37, Vmn2r4, Vmn2r41, Vmn2r43, Vmn2r45, Vmn2r47, Vmn2r49, Vmn2r50, Vmn2r52, Vmn2r54, Vmn2r56, VSTM2A, and ZFPL1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PGE1 (Prostaglandin E1), 1 mg | sc-201223 | 1 mg | $31.00 | |||
PGE1 (Prostaglandin E1), 10 mg | sc-201223A | 10 mg | $145.00 |