PACSIN1 Antibody (A-3): sc-166756

PACSIN1 Antibody (A-3) is a mouse monoclonal IgM antibody that detects PACSIN1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-PACSIN1 antibody (A-3) is available as a non-conjugated format. PACSIN1, a member of the PACSIN family of cytoplasmic adapter proteins, plays a crucial role in organizing the cytoskeleton, which is essential for maintaining cell shape, motility, and intracellular transport. PACSIN1 features a conserved C-terminal protein-binding SH3 domain and a CDC15-NT domain, which facilitate interactions with various signaling pathways. Notably, PACSIN1 expression is primarily found in terminally differentiated neural tissue, highlighting its importance in neuronal function and development. In contrast, PACSIN2, which is more widely expressed, exhibits a vesicle-like distribution and regulates endocytotic processes. PACSIN1′s ability to interact with specific proteins, such as syndapin 1, FAP52, EM13, and PSTPIP, further underscores its significance in cellular signaling and cytoskeletal dynamics, making anti-PACSIN1 antibody (A-3) a valuable tool for researchers studying these critical biological processes.

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PACSIN1 Antibody (A-3) References:

1. PACSIN 2, a novel member of the PACSIN family of cytoplasmic adapter proteins.  |  Ritter, B., et al. 1999. FEBS Lett. 454: 356-62. PMID: 10431838
2. PACSIN1 regulates the TLR7/9-mediated type I interferon response in plasmacytoid dendritic cells.  |  Esashi, E., et al. 2012. Eur J Immunol. 42: 573-9. PMID: 22488361
3. PACSIN1 regulates the dynamics of AMPA receptor trafficking.  |  Widagdo, J., et al. 2016. Sci Rep. 6: 31070. PMID: 27488904
4. Decreased Expression of PACSIN1 in Brain Glioma Samples Predicts Poor Prognosis.  |  Zimu, Z., et al. 2021. Front Mol Biosci. 8: 696072. PMID: 34422904
5. PACSIN1 is indispensable for amphisome-lysosome fusion during basal autophagy and subsets of selective autophagy.  |  Oe, Y., et al. 2022. PLoS Genet. 18: e1010264. PMID: 35771772
6. De Novo PACSIN1 Gene Variant Found in Childhood Lupus and a Role for PACSIN1/TRAF4 Complex in Toll-like Receptor 7 Activation.  |  Xie, C., et al. 2023. Arthritis Rheumatol. 75: 1058-1071. PMID: 36622335
7. PACSIN1 promotes immunosuppression in gastric cancer by degrading MHC-I.  |  Liu, Z., et al. 2024. Acta Biochim Biophys Sin (Shanghai). 56: 1473-1482. PMID: 38826133
8. Molecular cloning of an echinococcal microtrichal antigen immunoreactive in Echinococcus multilocularis disease.  |  Frosch, PM., et al. 1993. Mol Biochem Parasitol. 58: 301-10. PMID: 8479454
9. FAP52, a novel, SH3 domain-containing focal adhesion protein.  |  Meriläinen, J., et al. 1997. J Biol Chem. 272: 23278-84. PMID: 9287337
10. Tyrosine phosphorylation regulates the SH3-mediated binding of the Wiskott-Aldrich syndrome protein to PSTPIP, a cytoskeletal-associated protein.  |  Wu, Y., et al. 1998. J Biol Chem. 273: 5765-70. PMID: 9488710
11. PACSIN, a brain protein that is upregulated upon differentiation into neuronal cells.  |  Plomann, M., et al. 1998. Eur J Biochem. 256: 201-11. PMID: 9746365
12. Syndapin I, a synaptic dynamin-binding protein that associates with the neural Wiskott-Aldrich syndrome protein.  |  Qualmann, B., et al. 1999. Mol Biol Cell. 10: 501-13. PMID: 9950691

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PACSIN1 Antibody (A-3) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-PACSIN1 Antibody (A-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PACSIN1 Antibody (A-3) Specifications

Alternate Product Name: PACSIN1

Product Clone Name: A-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 364-381

Epitope Target: PACSIN1

Epitope Species: mouse

Product Reactivity/Detection: PACSIN1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for PACSIN1 Antibody (A-3): P: Blocking Peptide