p-p120 Antibody (pY228.21A): sc-136015

p-p120 Antibody (pY228.21A) is a mouse monoclonal IgG1 antibody that detects p120 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). p120, also known as cadherin-associated Src substrate, is a critical protein that plays a significant role in cellular adhesion and signaling pathways. p120 is a 968 amino acid tyrosine kinase substrate belonging to the beta-catenin family and is primarily expressed in vascular endothelium, where p120 localizes to the cytoplasm, nucleus, and cell membrane. p120 mediates ligand-induced receptor signaling through various growth factor receptors, including epidermal growth factor (EGF), platelet-derived growth factor (PDGF), colony-stimulating factor 1 (CSF-1), and Neu receptors. Additionally, p120 exhibits sequence homology with catenins at four distinct domains, which allows p120 to function effectively within E-cadherin complexes. p120 has four major isoforms, each generated through alternative splicing, and contains ten ARM repeats, which are crucial for structural integrity and function. Notably, p120 undergoes phosphorylation following translation, a post-translational modification that can influence activity and interactions, making p120 an essential component in the regulation of cell adhesion and signaling processes.

The preferred p120 antibody is p120 Antibody (15D2): sc-23872.