Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Nestin is a major intermediate filament (IF) protein of embryonic central nervous system progenitor cells. Nestin is also a component of the dynamic IF network during muscle development where it polymerizes with desmin and vimentin. Nestin co-assembles with vimentin or a-internexin and forms heterodimer coiled-coil molecules which then further assemble into 10 nm IFs. Deletion of the IF consensus rod domain in nestin alters nestin localization in CNS precursor cells and radial glial cells in vivo. Nestin is a marker for neuroepithelial stem cells, glioma cells, and tumor endothelial cells during rapid growth. During axon elongation of differentiation neurons, nestin localizes to the growth cones and may play a role in growth cone guidance. In the rat adrenal gland, nestin is expressed by the zona fasciculata and the zona reticularis. Nestin is also expressed by dermatomal cells and by myoblasts during the earliest stages of myogenesis. Thr 316 is a cdc2-specific phosphorylation site in Nestin. Phosphorylation at this site is increased during mitosis and is used as a marker for cdk5-specific phosphorylation. Cdk5 and cdc2 induces phosphorylation at both residues Thr 316 and Thr 1583.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.