Oxatomide (CAS 60607-34-3)

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別名: 1-[3-[4-(Diphenylmethyl)-1-piperazinyl]propyl]-1,3-dihydro-2H-benzimidazol-2-one

アプリケーション： Oxatomide is an H1-histamine receptor antagonist

CAS 番号: 60607-34-3

Purity: 99%

Molecular Weight: 426.55

Molecular Formula: C₂₇H₃₀N₄O

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* Refer to Certificate of Analysis for lot specific data (including water content).

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Oxatomide is a phenylpiperazine which acts as an H1 receptor antagonist. An interesting characteristic of Oxatomide is that it does not block acetylcholine in the central and peripheral nervous system. Studies conducted on guinea pigs show that Oxatomide suppresses PAF-induced bronchoconstriction and inhibits the release of leukotrienes and other mediators. Alternate studies show that the effectiveness of Oxatomide is not altered as a result of pretreating the cells with histamine, which is observed in other H1 receptor antagonists such as Fexofenadine (sc-218475). It is believed that Oxatomide's lipophilic properties allow it to cross the plasma membrane of cells.

参考文献

1. Ohmori, K., et al. 1983. Nippon Yakurigaku Zasshi. 81: 399-409. PMID: 6138301
2. Hishinuma, S., et al. 2008. J. Pharmacol. Sci. 107: 66-79. PMID: 18446005

Appearance :

Crystalline powder

Physical State :

Solid

Solubility :

Soluble in DMSO, ethanol, methanol, water, and chloroform.

保存方法 :

Store at 4° C

Melting Point :

153-154° C

Boiling Point :

621.1° C

Density :

1.18 g/cm³

Refractive Index :

n²⁰_D 1.62

Optical Activity :

α20/D +3°, c = 0.4 in water

IC50 :

Histamine H1 Receptor: IC₅₀ = 9 nM (human); Plasmodium falciparum: IC₅₀ = 3.98 µM; Cavia porcellus: IC₅₀ = 20.1 µM

pK Values :

pK_a: 12.2 (Predicted), pK_b: 7.5 (Predicted)

試験・研究用以外には使用しないでください。臨床及び体外診断には使用できません。

WGK Germany :

3

RTECS :

DE2276000

PubChem CID :

4615

Merck Index :

14: 6925

MDL Number :

MFCD00211147

EC Number :

262-320-9

Beilstein Registry :

4724760

SMILES :

C1CN(CCN1CCCN2C3=CC=CC=C3NC2=O)C(C4=CC=CC=C4)5=CC=CC=C5

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Oxatomide (CAS 60607-34-3)

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参考文献

Download SDS (MSDS)

分析表

Oxatomide (CAS 60607-34-3)

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参考文献

Download SDS (MSDS)

分析表

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