Oxatomide CAS: 60607-34-3
MF: C27H30N4O
MW: 426.55
An H1-histamine receptor antagonist.

Oxatomide (CAS 60607-34-3)

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別名: 1-[3-[4-(Diphenylmethyl)-1-piperazinyl]propyl]-1,3-dihydro-2H-benzimidazol-2-one
アプリケーション: Oxatomide is an H1-histamine receptor antagonist
CAS 番号: 60607-34-3
Purity: 99%
Molecular Weight: 426.55
Molecular Formula: C27H30N4O
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* Refer to Certificate of Analysis for lot specific data (including water content).

Oxatomide is a phenylpiperazine which acts as an H1 receptor antagonist. An interesting characteristic of Oxatomide is that it does not block acetylcholine in the central and peripheral nervous system. Studies conducted on guinea pigs show that Oxatomide suppresses PAF-induced bronchoconstriction and inhibits the release of leukotrienes and other mediators. Alternate studies show that the effectiveness of Oxatomide is not altered as a result of pretreating the cells with histamine, which is observed in other H1 receptor antagonists such as Fexofenadine (sc-218475). It is believed that Oxatomide's lipophilic properties allow it to cross the plasma membrane of cells.


参考文献

1. Ohmori, K., et al. 1983. Nippon Yakurigaku Zasshi. 81: 399-409. PMID: 6138301
2. Hishinuma, S., et al. 2008. J. Pharmacol. Sci. 107: 66-79. PMID: 18446005

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in DMSO, ethanol, methanol, water, and chloroform.
保存方法 :
Store at 4° C
Melting Point :
153-154° C
Boiling Point :
621.1° C
Density :
1.18 g/cm3
Refractive Index :
n20D 1.62
Optical Activity :
α20/D +3°, c = 0.4 in water
IC50 :
Histamine H1 Receptor: IC50 = 9 nM (human); Plasmodium falciparum: IC50 = 3.98 µM; Cavia porcellus: IC50 = 20.1 µM
pK Values :
pKa: 12.2 (Predicted), pKb: 7.5 (Predicted)
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WGK Germany :
3
RTECS :
DE2276000
PubChem CID :
Merck Index :
14: 6925
MDL Number :
MFCD00211147
EC Number :
262-320-9
Beilstein Registry :
4724760
SMILES :
C1CN(CCN1CCCN2C3=CC=CC=C3NC2=O)C(C4=CC=CC=C4)5=CC=CC=C5

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