Oleic Acid CAS: 112-80-1
MF: C18H34O2
MW: 282.46
An anti-proliferative agent and activator of PKC and CaMKII.

Oleic Acid (CAS 112-80-1)

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同義語 cis-9-Octadecenoic acid;Elainic acid
アプリケーション: An anti-proliferative agent and activator of PKC and CaMKII
CAS 番号: 112-80-1
Purity: ≥99%
Molecular Weight: 282.46
Molecular Formula: C18H34O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Oleic Acid, a monounsaturated fatty acid originally derived from Olea europaea, has been shown to be an anti-proliferative agent. This compound has also been reported to promote neuronal differentiation in murine cell cultures. Mechanistic studies suggest that these Oleic Acid effects are mediated by PPARβ. Furthermore, Oleic Acid has demonstrated the ability to stimulate an increase in secretion of collagen I, TGF-β secretion, and extracellular signal-regulated kinase1/2. Oleic Acid is an activator of PKC and CaMKII.


参考文献

1. Díaz-Guerra, M.J., et al. 1991. J. Biol. Chem. 266: 23568-23576. PMID: 1748635
2. Waterman, E., et al. 2007. Altern Med Rev. 12: 331-342. PMID: 18069902
3. Di Loreto, S., et al. 2007. J. Cell. Physiol. 211: 837-847. PMID: 17390299
4. Mishra, R., et al. 2008. Arterioscler. Thromb. Vasc. Biol. 28: 541-547. PMID: 18096831

Appearance :
Oil
Physical State :
Liquid
Solubility :
Soluble in ethanol (>25 mg/ml), ether, acetone, chloroform, DMF (100 mg/ml), DMSO (100 mg/ml), and PBS (pH 7.2) (<100 µg/ml).
保存方法 :
Store at -20° C
Melting Point :
13-14° C (lit.)
Boiling Point :
194-195° C (lit.) at 1.2 mmHg
Density :
0.89 g/mL at 25° C
Refractive Index :
n20D 1.46
IC50 :
DNA topoisomerase I: IC50 = 31000 nm (human); Fatty acid binding protein adipocyte: IC50 = 26100 nm (human)
Ki Data :
Fatty acid-binding protein, liver: Ki= 180 nm (Rattus norvegicus); Fatty acid binding protein adipocyte: Ki= 185 nm (human); Fatty acid binding protein epidermal: Ki= 248 nm (human)
pK Values :
pKa: 4.78
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
WGK Germany :
1
RTECS :
RG2275000
PubChem CID :
445639
Merck Index :
14: 6828
MDL Number :
MFCD00064242
EC Number :
204-007-1
Beilstein Registry :
1726542
SMILES :
CCCCCCCC/C=C\\CCCCCCCC(=O)O

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Oleic Acid  参考文献

See how others have used Oleic Acid. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 28819452  Chen, L. et al. 2017. Theranostics. 7: 2634-2648.

PMID: # 19808663  Kansanen, E. et al. 2009. J. Biol. Chem. 284: 33233-33241.

PMID: # 32157714  J. Food Biochem. e13177.

Citations 1 to 3 of 3 total
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