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NGF 抗体 (NGF30): sc-32300

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说明书
  • NGF 抗体 NGF30 是大鼠单克隆 IgG1, 在12篇文献中引用,提供 200 µg/ml
  • 免疫mouse物种的NGF
  • 推荐用于 mouse 和 rat 来源的native and denatured NGF WB, IP 和 IF检测
  • 目前,我们还没有完成NGF 抗体 (NGF30)的首选二抗检测试剂的鉴定。这项工作正在进行中。
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NGF抗体(NGF30)是一种鼠单克隆IgG1抗体,针对小鼠来源的神经生长因子(NGF)产生,能够通过蛋白质印迹(WB)、免疫沉淀(IP)和免疫荧光(IF)检测小鼠和大鼠的天然和变性NGF。NGF也称为β-神经生长因子,是一种重要的神经营养因子,参与调节神经元的存活、发育和功能。NGF在发育过程中促进交感神经和感觉神经元的存活和分化,并在成人神经系统的神经可塑性和修复过程中发挥关键作用。NGF主要通过与高亲和力受体TrkA(肌动蛋白受体激酶A)结合发挥其作用,但也可以与低亲和力受体p75NTR相互作用,影响多种细胞内信号通路。NGF表达或信号传导失调与阿尔茨海默病和周围神经病变等神经退行性疾病有关,因此NGF成为重要的研究对象。抗NGF抗体(NGF30)是科学家研究NGF在神经元存活、生长和潜在治疗应用中作用的重要工具。NGF单克隆抗体(NGF30)有助于加深我们对神经营养因子介导的信号通路及其在神经系统疾病中的意义的理解。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

NGF 抗体 (NGF30) 参考文献:

  1. 中枢神经系统的神经生长因子:实验数据和临床意义。  |  Ebendal, T. 1989. Prog Growth Factor Res. 1: 143-59. PMID: 2562358
  2. 中枢神经系统的NGF代谢途径及其在唐氏综合征和阿尔茨海默病中的失调。  |  Iulita, MF. and Cuello, AC. 2016. Curr Alzheimer Res. 13: 53-67. PMID: 26391047
  3. NGF/TrkA信号传导作为疼痛的治疗靶点。  |  Hirose, M., et al. 2016. Pain Pract. 16: 175-82. PMID: 26452158
  4. 神经生长因子在神经和免疫系统的早期胚胎发生、分化及病理中的作用。  |  Bracci-Laudiero, L. and De Stefano, ME. 2016. Curr Top Behav Neurosci. 29: 125-152. PMID: 26695167
  5. 神经生长因子依赖性神经元与情绪和感觉的神经生物学:先天性无痛无汗症的启示。  |  Indo, Y. 2018. Neurosci Biobehav Rev. 87: 1-16. PMID: 29407522
  6. 神经生长因子对精子特性的作用:综述。  |  Castellini, C., et al. 2020. Theriogenology. 150: 210-214. PMID: 32000995
  7. 神经生长因子(NGF)与动物繁殖。  |  Maranesi, M., et al. 2021. Adv Exp Med Biol. 1331: 277-287. PMID: 34453306
  8. NGF 信号与 Hippo/YAP 通路相互作用,调控宫颈癌的进展  |  Wang, L., et al. 2021. Front Oncol. 11: 688794. PMID: 34722240
  9. 神经生长因子与阿尔茨海默氏症的治疗。  |  Olson, L. 1993. Exp Neurol. 124: 5-15. PMID: 8282080
  10. 神经生长因子作为炎症性疼痛的介质。  |  McMahon, SB. 1996. Philos Trans R Soc Lond B Biol Sci. 351: 431-40. PMID: 8730782

订购信息

产品名称产品编号规格价格数量收藏夹

NGF 抗体 (NGF30)

sc-32300
200 µg/ml
$322.00

Are there any issues with using sc-32300: NGF (NGF30) mouse monoclonal primary antibody on mouse samples?

Asked by: jenniferc
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent,we recommend using a directly conjugated primary antibody. Please contact our special orders department for pricing and availability of sc-32300 conjugates.
Answered by: Technical Support
Date published: 2017-03-07
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Rated 3 out of 5 by SM from Positive detection of mouse recombinantPositive detection of mouse recombinant -NGF by WB. Large, bulbous band observed. WB ran under non-reducing conditions. -SCBT QC
Date published: 2015-04-19
Rated 3 out of 5 by JT from Good data with human gastric cancer tissueGood data with human gastric cancer tissue. -SCBT Publication Review
Date published: 2015-03-19
Rated 3 out of 5 by LM from Publishable data obtained by IHC using human PANCPublishable data obtained by IHC using human PANC-1 cells. -SCBT Publication Review
Date published: 2014-11-16
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NGF 抗体 (NGF30) is rated 3.0 out of 5 by 3.
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