m-IgGκ BP-HRP (mouse IgGκ binding protein-HRP) is the preferred detection reagent for Neurabin-II Antibody (D-7) for WB and IHC(P) applications. This reagent is now offered in a bundle with Neurabin-II Antibody (D-7) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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Neurabin-II Antibody (D-7) is a high quality monoclonal Neurabin-II antibody (also designated Neurabin-II antibody) suitable for the detection of the Neurabin-II protein of human origin. Neurabin-II Antibody (D-7) is available as both the non-conjugated anti-Neurabin-II antibody form, as well as multiple conjugated forms of anti-Neurabin-II antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Neurabin-II, also called spinophilin, interacts with actin and PP-1 in dendritic spines of the central nervous system. The gene encoding human neurabin-II maps to chromosome 17q21-q22. The structural characteristics of neurabin-II include one F-actin binding domain at the N-terminal region, a predicted coiled-coil struture at the C-terminal, one PDZ domain at the middle region, and a domain known to interact with transmembrane proteins. Neurabin-II bundles actin fliaments in vitro. In vivo, spinophilin localizes to the cortical sites of actin filaments and to the sites of active membrane remodelling. Neurabin-II also forms a complex with the catalytic subunit of PP1 and modulates PP1 enzymatic activity in vitro. Neurabin-II localizes to the head of dendritic spines and aids in the ability of PP-1 to regulate the activity of a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and N-methyl-D-asparate (NMDA) receptors. In this manner, neurabin-II modulates both glutamatergic synaptic transmission and dendritic morphology. Synergistic interactions between spinophilin and human tumor supressor ARF suggest a role for neurabin-II in cell growth.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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