NALP7 Antibody (C-8): sc-377190

NALP7 Antibody (C-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects NALP7 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). NALP7 (C-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. NALP7, also known as PYPAF3, plays a critical role in regulating inflammatory responses by inhibiting interleukin-1 beta (IL-1β) secretion through direct interaction with caspase-1. This function is particularly important as IL-1β is a key mediator in the inflammatory process, and dysregulation can lead to various inflammatory diseases. NALP7 is predominantly expressed in tissues such as the uterus and ovary, with lower expression levels in the heart and brain, indicating potential involvement in reproductive health and inflammatory responses in these tissues. Mutations or defects in NALP7 are associated with hydatidiform moles, which are abnormal pregnancies characterized by cystic degeneration of placental villi and absence of an embryo. Studies have shown that silencing NALP7 via RNA interference can inhibit carcinoma cell line growth, suggesting a significant role in cell proliferation and cancer biology. NALP7 is located on chromosome 19q13.42, within a cluster of other NALP genes, highlighting evolutionary significance and potential functional redundancy within this gene family.

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NALP7 Antibody (C-8) References:

1. Genetic mapping of a maternal locus responsible for familial hydatidiform moles.  |  Moglabey, YB., et al. 1999. Hum Mol Genet. 8: 667-71. PMID: 10072436
2. Familial recurrent molar pregnancy: a case report.  |  Agarwal, P., et al. 2004. Acta Obstet Gynecol Scand. 83: 213-4. PMID: 14756744
3. Oncogenic role of NALP7 in testicular seminomas.  |  Okada, K., et al. 2004. Cancer Sci. 95: 949-54. PMID: 15596043
4. PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1beta secretion.  |  Kinoshita, T., et al. 2005. J Biol Chem. 280: 21720-5. PMID: 15817483
5. Induction of toll-like receptors and NALP/PAN/PYPAF family members by modified oligonucleotides in lung epithelial carcinoma cells.  |  Drygin, D., et al. 2005. Oligonucleotides. 15: 105-18. PMID: 15989425
6. Mutations in NALP7 cause recurrent hydatidiform moles and reproductive wastage in humans.  |  Murdoch, S., et al. 2006. Nat Genet. 38: 300-2. PMID: 16462743
7. NLRP7 or KHDC3L genes and the etiology of molar pregnancies and recurrent miscarriage.  |  Andreasen, L., et al. 2013. Mol Hum Reprod. 19: 773-81. PMID: 23963444
8. No evidence for mutations in NLRP7, NLRP2 or KHDC3L in women with unexplained recurrent pregnancy loss or infertility.  |  Aghajanova, L., et al. 2015. Hum Reprod. 30: 232-8. PMID: 25376457
9. NLRP7 deubiquitination by USP10 promotes tumor progression and tumor-associated macrophage polarization in colorectal cancer.  |  Li, B., et al. 2021. J Exp Clin Cancer Res. 40: 126. PMID: 33838681
10. Role of NLRP7 in Normal and Malignant Trophoblast Cells.  |  Abi Nahed, R., et al. 2022. Biomedicines. 10: PMID: 35203462
11. NLRP7 Enhances Choriocarcinoma Cell Survival and Camouflage in an Inflammasome Independent Pathway.  |  Reynaud, D., et al. 2023. Cells. 12: PMID: 36980199
12. NLRP7 participates in the human subcortical maternal complex and its variants cause female infertility characterized by early embryo arrest.  |  Han, J., et al. 2023. J Mol Med (Berl). 101: 717-729. PMID: 37148315

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-NALP7 Antibody (C-8) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-NALP7 Antibody (C-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

NALP7 Antibody (C-8) Specifications

Alternate Product Name: NALP7

Product Clone Name: C-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 16-170

Epitope Target: NALP7

Epitope Species: human

Product Reactivity/Detection: NALP7 isoforms 1 and 2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for NALP7 Antibody (C-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin