Metallothionein 3 Antibody (1F11): sc-293488

Metallothionein 3 Antibody (1F11) is a mouse monoclonal IgG2b kappa light chain antibody that detects the Metallothionein 3 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Metallothionein 3 antibody (1F11) is available as a non-conjugated format. Metallothionein 3, also known as MT-3 or GIFB (growth inhibitory factor), is a 68 amino acid protein that belongs to the type 1 family and Metallothionein superfamily. Metallothionein 3 plays a crucial role in the central nervous system, particularly in the brain, where Metallothionein 3 is highly expressed in astrocytes. Metallothionein 3 is vital for neuroprotection, as Metallothionein 3 helps to mitigate oxidative stress and metal ion toxicity, which are significant factors in neurodegenerative diseases. Notably, Metallothionein 3 expression is reduced in the brains of patients with Alzheimer′s disease, suggesting a potential role in the pathophysiology of this condition. Additionally, Metallothioneins are known for binding heavy metals, thereby providing cellular protection against cadmium, mercury, and copper toxicity. Metallothionein 3′s broad expression in various tissues, including the heart, liver, kidney, breast, and testis, underscores Metallothionein 3′s importance in cellular growth, repair, and differentiation.

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Metallothionein 3 Antibody (1F11) References:

1. Infiltrating lymphocytes in undifferentiated nasopharyngeal cancer lack metallothionein expression.  |  Jayasurya, A., et al. 2000. Cancer Lett. 155: 99-104. PMID: 10814885
2. Metallothionein-I/II null mice are more sensitive than wild-type mice to the hepatotoxic and nephrotoxic effects of chronic oral or injected inorganic arsenicals.  |  Liu, J., et al. 2000. Toxicol Sci. 55: 460-7. PMID: 10828279
3. Metallothionein inhibits myocardial apoptosis in copper-deficient mice: role of atrial natriuretic peptide.  |  Kang, YJ., et al. 2000. Lab Invest. 80: 745-57. PMID: 10830785
4. Liver metallothionein expression in thioacetamide-intoxicated rats.  |  Theocharis, SE., et al. 2000. Pathol Res Pract. 196: 313-9. PMID: 10834388
5. Induction of metallothionein synthesis with preservation of testicular function in rats following long term renal transplantation.  |  Cai, L., et al. 2000. Urol Res. 28: 97-103. PMID: 10850631
6. Metallothione in levels in cell fractions from breast cancer tissues.  |  Floriañczyk, B. and Grzybowska, L. 2000. Acta Oncol. 39: 141-3. PMID: 10859002
7. Immunohistochemical localization of metallothionein in endometrial lesions.  |  Ioachim, EE., et al. 2000. J Pathol. 191: 269-73. PMID: 10878548
8. Cloning and sequencing of cDNAs encoding for a novel copper-specific metallothionein and two cadmium-inducible metallothioneins from the blue crab Callinectes sapidus.  |  Syring, RA., et al. 2000. Comp Biochem Physiol C Toxicol Pharmacol. 125: 325-32. PMID: 11790353
9. MT-III, a brain-specific member of the metallothionein gene family.  |  Palmiter, RD., et al. 1992. Proc Natl Acad Sci U S A. 89: 6333-7. PMID: 1631128
10. The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein.  |  Uchida, Y., et al. 1991. Neuron. 7: 337-47. PMID: 1873033

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Metallothionein 3 Antibody (1F11) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Metallothionein 3 Antibody (1F11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Metallothionein 3 Antibody (1F11) Specifications

Alternate Product Name: Metallothionein 3

Product Clone Name: 1F11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 1-68

Epitope Target: Metallothionein 3

Epitope Species: human

Product Reactivity/Detection: Metallothionein 3

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Metallothionein 3 Antibody (1F11): N/A