Mengo 3DPol Antibody (8D10): sc-65632

Mengo 3DPol Antibody (8D10) is a mouse monoclonal IgG2a antibody that detects 3DPol protein by western blotting (WB). Anti-3DPol antibody (8D10) specifically targets the RNA-dependent RNA polymerase (3Dpol) of the Mengovirus, a member of the Cardiovirus genus within the Picornaviridae family. 3DPol (8D10) monoclonal antibody recognizes this essential enzyme responsible for synthesizing new viral RNA genomes, facilitating viral replication and propagation within the host. Understanding 3Dpol function is vital for developing antiviral strategies and assessing Mengovirus infection in mammalian systems. Anti-3DPol antibody (8D10) accurately detects this polymerase, enabling researchers to monitor viral replication dynamics and explore mechanisms of Mengovirus host immune evasion, making this tool valuable for virology studies.

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Mengo 3DPol Antibody (8D10) References:

1. Picornavirus RNA-dependent RNA polymerase.  |  Kok, CC. and McMinn, PC. 2009. Int J Biochem Cell Biol. 41: 498-502. PMID: 18487072
2. Enterovirus 71 VPg uridylation uses a two-molecular mechanism of 3D polymerase.  |  Sun, Y., et al. 2012. J Virol. 86: 13662-71. PMID: 23055549
3. SUMO Modification Stabilizes Enterovirus 71 Polymerase 3D To Facilitate Viral Replication.  |  Liu, Y., et al. 2016. J Virol. 90: 10472-10485. PMID: 27630238
4. Transient Chemogenetic Inhibition of D1-MSNs in the Dorsal Striatum Enhances Methamphetamine Self-Administration.  |  Oliver, RJ., et al. 2019. Brain Sci. 9: PMID: 31752398
5. Host-Specific Interplay between Foot-and-Mouth Disease Virus 3D Polymerase and the Type-I Interferon Pathway.  |  Sarry, M., et al. 2023. Viruses. 15: PMID: 36992375
6. Down-regulated TAB1 suppresses the replication of Coxsackievirus B5 via activating the NF-κB pathways through interaction with viral 3D polymerase.  |  Zhang, J., et al. 2023. Virol J. 20: 291. PMID: 38072991
7. Interleukin-2 enhancer binding factor 2 negatively regulates the replication of duck hepatitis A virus type 1 by disrupting the RNA-dependent RNA polymerase activity of 3D polymerase.  |  An, H., et al. 2024. Vet Res. 55: 40. PMID: 38532469
8. The nucleoside analog 4'-fluorouridine suppresses the replication of multiple enteroviruses by targeting 3D polymerase.  |  Chen, Y., et al. 2024. Antimicrob Agents Chemother. 68: e0005424. PMID: 38687016
9. AIMP2 restricts EV71 replication by recruiting SMURF2 to promote the degradation of 3D polymerase.  |  Ren, J., et al. 2024. Virol Sin. 39: 632-644. PMID: 38945214
10. Epitope mapping of monoclonal antibodies raised to recombinant Mengo 3D polymerase.  |  Duque, H. and Palmenberg, AC. 1996. Virus Genes. 13: 159-68. PMID: 8972569

The preferred Mengo 3DPol antibody is Mengo 3DPol Antibody (3B7): sc-65633.