Thank you for your question. Each Double Nickase product (m and m2) are made using different guide RNA's, both of which target the specific gene of interest. You can use either one, both are recommended and warrantied to knock out the MCP-1 gene. If you have any further questions, please contact our Asia Technical Service team. You can reach them by phone at (86 21) 6093-6350, by email at: [email protected]
or by live chat directly on our website, www.scbt.com. Alternatively, you can contact one of our authorized distributors in Japan, you can find their contact information here: https://www.scbt.com/scbt/resources/distributors.