Ku86 Antibody (S10B1): sc-56136
- Ku86 Antibody (S10B1) is a mouse monoclonal IgG1 κ, cited in 5 publications, provided at 200 µg/ml
- raised against placental cell extract of human origin, with epitope mapping to amino acids 8-221
- recommended for detection of Ku86 of human origin by WB, IP, IF and IHC(P)
- See Ku86 (B-1): sc-5280 for Ku86 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for Ku86 Antibody (S10B1) for WB and IHC(P) applications. This reagent is now offered in a bundle with Ku86 Antibody (S10B1) (see ordering information below).
Ku86 Antibody (S10B1) is a mouse monoclonal IgG1 antibody that detects Ku86 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Ku86, also known as Ku80 or p80, is a critical component of the Ku protein complex, which is essential for DNA repair and maintenance of genomic stability. Ku86 is primarily localized in the nucleus, where Ku86 plays a vital role in the cellular response to DNA damage by binding to double-stranded breaks and facilitating the recruitment of DNA repair machinery. The Ku86 subunit, along with Ku70, forms a heterodimer that not only protects DNA ends but also acts as a regulatory component of the DNA-dependent protein kinase, which is crucial for the phosphorylation of key proteins involved in DNA repair and transcription. The interaction of Ku86 with various proteins, including the DNA-dependent protein kinase catalytic subunit (DNA-PKcs), underscores Ku86′s importance in the DNA damage response pathway, making Ku86 a significant target for research in cancer biology and therapeutic interventions. Anti-Ku86 antibody (S10B1) is an invaluable tool for studying the dynamics of DNA repair mechanisms and the role of Ku proteins in cellular processes.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ku86 Antibody (S10B1) | sc-56136 | 200 µg/ml | $322.00 | |||
Ku86 Antibody (S10B1): m-IgG Fc BP-HRP Bundle | sc-551933 | 200 µg Ab; 10 µg BP | $361.00 |