JAB1 Antibody (G-10): sc-393725
- JAB1 Antibody (G-10) is a mouse monoclonal IgG2b κ, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 2-21 at the N-terminus of JAB1 of human origin
- recommended for detection of JAB1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and canine, bovine and porcine
- TransCruz reagent for ChIP application (sc-393725 X, 200 µg/0.1 ml)
- See JAB1 (B-7): sc-13157 for JAB1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for JAB1 Antibody (G-10) for WB applications. These reagents are now offered in bundles with JAB1 Antibody (G-10) (see ordering information below).
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JAB1 Antibody (G-10) is a mouse monoclonal IgG2b antibody that detects JAB1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). JAB1, also known as Jun-activation domain-binding protein 1, plays a crucial role in regulating the activity of c-Jun, a key component of the AP-1 transcription factor complex. By enhancing the transactivating ability of Jun proteins, JAB1 stabilizes their binding to the TPA-response element, which is vital for the expression of genes involved in cell proliferation and survival. This interaction is particularly important in the context of oncogenic signaling, as JAB1 can influence the transcriptional response to various stimuli, including growth factors and tumor promoters. The gene encoding JAB1 is located on human chromosome 8q12.3, and JAB1 expression is tightly regulated, highlighting JAB1′s significance in cellular processes and potential implications in cancer biology. Anti-JAB1 antibody (G-10) is an essential tool for researchers studying the molecular mechanisms of transcriptional regulation and JAB1′s role in various physiological and pathological contexts.
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JAB1 Antibody (G-10) References:
- Jab1/CSN5 negatively regulates p27 and plays a role in the pathogenesis of nasopharyngeal carcinoma. | Pan, Y., et al. 2012. Cancer Res. 72: 1890-900. PMID: 22350412
- Jab1 regulates Schwann cell proliferation and axonal sorting through p27. | Porrello, E., et al. 2014. J Exp Med. 211: 29-43. PMID: 24344238
- Loss of jab1 in osteochondral progenitor cells severely impairs embryonic limb development in mice. | Bashur, LA., et al. 2014. J Cell Physiol. 229: 1607-17. PMID: 24604556
- JAB1 and phospho-Ser10 p27 expression profile determine human hepatocellular carcinoma prognosis. | Wang, Y., et al. 2014. J Cancer Res Clin Oncol. 140: 969-78. PMID: 24671224
- Jab1/Csn5-Thioredoxin Signaling in Relapsed Acute Monocytic Leukemia under Oxidative Stress. | Zhou, F., et al. 2017. Clin Cancer Res. 23: 4450-4461. PMID: 28270496
- S100A7, Jab1, and p27kip1 expression in psoriasis and S100A7 CRISPR-activated human keratinocyte cell line. | Granata, M., et al. 2019. J Cell Biochem. 120: 3384-3392. PMID: 30203426
- Overexpression of JAB1 promotes malignant behavior and predicts poor prognosis in esophageal squamous cell carcinoma. | Shen, Q., et al. 2020. Thorac Cancer. 11: 973-982. PMID: 32064781
- Targeting Jab1 using hesperidin (dietary phytocompound) for inducing apoptosis in HeLa cervical cancer cells. | Pandey, P., et al. 2021. J Food Biochem. 45: e13800. PMID: 34047379
- JAB1 deletion in oligodendrocytes causes senescence-induced inflammation and neurodegeneration in mice. | Rivellini, C., et al. 2022. J Clin Invest. 132: PMID: 34874913
- Pan-cancer analyses of Jab1/COPS5 reveal oncogenic role and clinical outcome in human cancer. | Wang, L., et al. 2022. Heliyon. 8: e12553. PMID: 36643321
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
JAB1 Antibody (G-10) | sc-393725 | 200 µg/ml | $322.00 | |||
JAB1 Antibody (G-10): m-IgG Fc BP-HRP Bundle | sc-538293 | 200 µg Ab; 10 µg BP | $361.00 | |||
JAB1 Antibody (G-10): m-IgGκ BP-HRP Bundle | sc-535874 | 200 µg Ab; 40 µg BP | $361.00 | |||
JAB1 Antibody (G-10): m-IgG2b BP-HRP Bundle | sc-549935 | 200 µg Ab; 10 µg BP | $361.00 | |||
JAB1 (G-10) Neutralizing Peptide | sc-393725 P | 100 µg/0.5 ml | $69.00 | |||
JAB1 Antibody (G-10) X | sc-393725 X | 200 µg/0.1 ml | $322.00 |