HYPE Antibody (3F5): sc-517074
- HYPE Antibody (3F5) is a mouse monoclonal IgG2a κ provided at 100 µg/ml
- raised against amino acids 1-449 representing full length HYPE of human origin
- recommended for detection of HYPE of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for HYPE Antibody (3F5). This work is in progress.
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HYPE Antibody (3F5) is a mouse monoclonal IgG2a antibody that detects HYPE in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). HYPE, also known as Huntingtin yeast partner E or FIC domain-containing protein, is a 458 amino acid single-pass membrane protein that plays a critical role in cellular processes by interacting with the Huntingtin protein, which is implicated in neurodegenerative diseases when mutated. The presence of two tetratricopeptide repeats (TPR) in HYPE suggests involvement in protein-protein interactions, which are essential for various signaling pathways and cellular functions. Understanding HYPE interactions is vital, as these may influence the pathogenesis of Huntington′s disease and other neurodegenerative disorders. The gene encoding HYPE is located on chromosome 12, a region associated with several skeletal deformities and crucial gene clusters that regulate morphogenesis and immune responses. Anti-HYPE antibody (3F5) effectively detects HYPE in various applications, making this reagent an invaluable tool for researchers studying molecular mechanisms underlying neurodegeneration and broader implications of chromosome 12 in human health.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HYPE Antibody (3F5) | sc-517074 | 100 µg/ml | $322.00 |