hnRNP M Antibody (5-RE36): sc-134360
- hnRNP M Antibody (5-RE36) is a mouse monoclonal IgG2a κ, cited in 5 publications, provided at 100 µg/ml
- raised against recombinant hnRNP M protein of human origin
- recommended for detection of hnRNP M of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- See hnRNP M1-4 (1D8): sc-20002 for hnRNP M antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for hnRNP M Antibody (5-RE36). This work is in progress.
hnRNP M Antibody (5-RE36) is a mouse monoclonal IgG2a antibody that detects hnRNP M in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). hnRNP M plays a crucial role in pre-mRNA splicing, a vital process that ensures the correct maturation of mRNA before translation into proteins. hnRNP M is primarily located in the nucleus, where hnRNP M participates in the assembly of spliceosomal complexes, which are essential for the removal of introns from pre-mRNA. Proper functioning of hnRNP M is important because any dysregulation in splicing can lead to various diseases, including cancer and neurodegenerative disorders. hnRNP M is also involved in stress-induced transient splicing arrest, highlighting hnRNP M′s role in cellular responses to environmental changes. With diverse functions and significance in gene expression regulation, hnRNP M remains a critical protein for researchers studying mRNA processing and its implications in health and disease.
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hnRNP M Antibody (5-RE36) References:
- Cell type-restricted activity of hnRNPM promotes breast cancer metastasis via regulating alternative splicing. | Xu, Y., et al. 2014. Genes Dev. 28: 1191-203. PMID: 24840202
- In vitro identification of nonalcoholic fatty liver disease-related protein hnRNPM. | Takino, J., et al. 2015. World J Gastroenterol. 21: 1784-93. PMID: 25684943
- Coregulation of alternative splicing by hnRNPM and ESRP1 during EMT. | Harvey, SE., et al. 2018. RNA. 24: 1326-1338. PMID: 30042172
- RNA-recognition motif in Matrin-3 mediates neurodegeneration through interaction with hnRNPM. | Ramesh, N., et al. 2020. Acta Neuropathol Commun. 8: 138. PMID: 32811564
- hnRNPM deficiency leads to cognitive deficits via disrupting synaptic plasticity. | Akinyemi, AR., et al. 2021. Neurosci Lett. 751: 135824. PMID: 33727124
- circPTPN12 promotes the progression and sunitinib resistance of renal cancer via hnRNPM/IL-6/STAT3 pathway. | Shou, Y., et al. 2023. Cell Death Dis. 14: 232. PMID: 37002206
- The bovine leukemia virus-derived long non-coding RNA AS1-S binds to bovine hnRNPM and alters the interaction between hnRNPM and host mRNAs. | Andoh, K., et al. 2023. Microbiol Spectr. 11: e0085523. PMID: 37671887
- Circular RNA-circLRP6 protects cardiomyocyte from hypoxia-induced apoptosis by facilitating hnRNPM-mediated expression of FGF-9. | Ding, W., et al. 2024. FEBS J. 291: 1246-1263. PMID: 38105623
- RNA-binding proteins hnRNPM and ELAVL1 promote type-I interferon induction downstream of the nucleic acid sensors cGAS and RIG-I. | Kirchhoff, A., et al. 2025. EMBO J. 44: 824-853. PMID: 39707025
- HnRNPM modulates alternative splicing in germ cells by recruiting PTBP1. | Lv, P., et al. 2025. Reprod Biol Endocrinol. 23: 3. PMID: 39780247
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
hnRNP M Antibody (5-RE36) | sc-134360 | 100 µg/ml | $339.00 |