Hep B Pol Antibody (9F9): sc-81592
- Hep B Pol Antibody (9F9) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against recombinant Hepatitis B Polymerase
- recommended for detection of amino acids 800-832 corresponding to the RNase H domain of Hepatitis B polymerase of Hepatitis B origin by WB, IP and IF
- See Hep B Pol (2C8): sc-81590 for Hep B Pol antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Hep B Pol Antibody (9F9). This work is in progress.
QUICK LINKS
SEE ALSO...
Hep B Pol Antibody (9F9) is a mouse monoclonal IgG1 antibody that detects Hepatitis B polymerase (Hep B Pol) protein of Hepatitis B by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-Hep B Pol antibody (9F9) plays a crucial role in understanding Hep B Pol protein, which is an essential enzyme involved in the transcription of Hepatitis B RNA genome into double-stranded DNA within viral capsids. Hep B Pol (9F9) monoclonal antibody enables research into Hep B Pol protein′s interactions with cellular factors, including heat shock proteins HSP 70 and HSP 40, which are vital for activation. These interactions with host proteins underscore Hep B Pol′s importance in the viral life cycle and potential as a therapeutic target. Hep B Pol (9F9) antibody helps researchers study the terminal protein domain specific to Hepadnaviruses, revealing unique structural features critical for function. Anti-Hep B Pol antibody (9F9) provides valuable insights into Hepatitis B virus replication mechanisms and potential antiviral strategies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Hep B Pol Antibody (9F9) References:
- Character of HBV (hepatitis B virus) polymerase gene rtM204V/I and rtL180M mutation in patients with lamivudine resistance. | Li, MW., et al. 2005. J Zhejiang Univ Sci B. 6: 664-7. PMID: 15973769
- Nucleoside/nucleotide analog inhibitors of hepatitis B virus polymerase: mechanism of action and resistance. | Menéndez-Arias, L., et al. 2014. Curr Opin Virol. 8: 1-9. PMID: 24814823
- Hepatitis B virus polymerase disrupts K63-linked ubiquitination of STING to block innate cytosolic DNA-sensing pathways. | Liu, Y., et al. 2015. J Virol. 89: 2287-300. PMID: 25505063
- Mutations in hepatitis B virus polymerase are associated with the postoperative survival of hepatocellular carcinoma patients. | Yin, F., et al. 2017. PLoS One. 12: e0189730. PMID: 29287068
- Non-nucleoside hepatitis B virus polymerase inhibitors identified by an in vitro polymerase elongation assay. | Nakajima, S., et al. 2020. J Gastroenterol. 55: 441-452. PMID: 31768802
- Hepatitis B Virus DNA Polymerase Restrains Viral Replication Through the CREB1/HOXA Distal Transcript Antisense RNA Homeobox A13 Axis. | Zhao, X., et al. 2021. Hepatology. 73: 503-519. PMID: 32314410
- Preparation and functional evaluation of monoclonal antibodies targeting Hepatitis B Virus Polymerase. | Hu, S., et al. 2021. Virulence. 12: 188-194. PMID: 33356842
- Identification of novel hepatitis B virus therapeutic vaccine candidates derived from polymerase protein. | Zheng, J., et al. 2021. Aging (Albany NY). 13: 14372-14384. PMID: 34016795
- Hepatitis B virus polymerase-specific T cell epitopes shift in a mouse model of chronic infection. | Hasanpourghadi, M., et al. 2021. Virol J. 18: 242. PMID: 34876153
- Development and characterization of a chronic hepatitis B murine model with a mutation in the START codon of an HBV polymerase. | Vanekova, L., et al. 2023. Physiol Res. 72: 37-47. PMID: 36545874
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Hep B Pol Antibody (9F9) | sc-81592 | 200 µg/ml | $322.00 |