HADHSC Antibody (LB-7): sc-100472
- HADHSC Antibody (LB-7) is a mouse monoclonal IgG2b κ, cited in 1 publications, provided at 100 µg/ml
- raised against recombinant HADHSC of human origin
- recommended for detection of HADHSC of human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for HADHSC Antibody (LB-7). This work is in progress.
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HADHSC Antibody (LB-7) is a mouse monoclonal IgG2b antibody that detects hydroxyacyl-Coenzyme A (CoA) dehydrogenase, short chain (HADHSC) in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). HADHSC is a crucial mitochondrial matrix protein predominantly expressed in the pancreas, liver, heart, kidney, and skeletal muscle, where HADHSC plays a vital role in lipid metabolism by facilitating the β-oxidation of medium and short-chain fatty acids. HADHSC functions as a homodimer, catalyzing the conversion of 3-hydroxyacyl-CoAs to their corresponding 3-ketoacyl-CoAs while simultaneously reducing NAD+ to NADH, a process essential for energy production and metabolic regulation. Deficiencies in HADHSC can lead to serious metabolic disorders, including 3-α-hydroxyacyl-CoA dehydrogenase deficiency and familial hyperinsulinemic hypoglycemia 4, both of which can result in severe clinical manifestations such as hypoglycemia, myopathy, and even sudden death if not properly managed. Anti-HADHSC antibody (LB-7) is an invaluable tool for researchers studying these metabolic pathways and their implications in human health and disease.
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HADHSC Antibody (LB-7) References:
- Genetics and pathophysiology of hyperinsulinism in infancy. | Cosgrove, KE., et al. 2004. Horm Res. 61: 270-88. PMID: 14981344
- Foxa2 regulates multiple pathways of insulin secretion. | Lantz, KA., et al. 2004. J Clin Invest. 114: 512-20. PMID: 15314688
- The HADHSC gene encoding short-chain L-3-hydroxyacyl-CoA dehydrogenase (SCHAD) and type 2 diabetes susceptibility: the DAMAGE study. | van Hove, EC., et al. 2006. Diabetes. 55: 3193-6. PMID: 17065362
- Functional genomics of the beta-cell: short-chain 3-hydroxyacyl-coenzyme A dehydrogenase regulates insulin secretion independent of K+ currents. | Hardy, OT., et al. 2007. Mol Endocrinol. 21: 765-73. PMID: 17185391
- Specificity in beta cell expression of L-3-hydroxyacyl-CoA dehydrogenase, short chain, and potential role in down-regulating insulin release. | Martens, GA., et al. 2007. J Biol Chem. 282: 21134-44. PMID: 17491019
- Short-chain 3-hydroxyacyl-CoA dehydrogenase is a negative regulator of insulin secretion in response to fuel and non-fuel stimuli in INS832/13 β-cells. | Pepin, E., et al. 2010. J Diabetes. 2: 157-67. PMID: 20923481
- Identification of gene signatures used to recognize biological characteristics of gastric cancer upon gene expression data. | Yan, Z., et al. 2014. Biomark Insights. 9: 67-76. PMID: 25210421
- Weight loss-induced changes in adipose tissue proteins associated with fatty acid and glucose metabolism correlate with adaptations in energy expenditure. | Camps, SG., et al. 2015. Nutr Metab (Lond). 12: 37. PMID: 26500687
- Abnormal expression of HADH, an enzyme of fatty acid oxidation, affects tumor development and prognosis (Review). | Wang, X., et al. 2022. Mol Med Rep. 26: PMID: 36239258
- Structural organization of the human short-chain L-3-hydroxyacyl-CoA dehydrogenase gene. | Vredendaal, PJ., et al. 1998. Mamm Genome. 9: 763-8. PMID: 9716664
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HADHSC Antibody (LB-7) | sc-100472 | 100 µg/ml | $339.00 |