HADHSC Activators
HADHSC Activators are a class of compounds that indirectly enhance the functional activity of HADHSC by influencing the presence of substrates and the regulatory mechanisms of fatty acid oxidation within mitochondrial matrices. Acetyl-CoA and NAD+ are pivotal to the HADHSC catalytic process, serving respectively as a substrate and a coenzyme necessary for the oxidation of L-3-hydroxyacyl CoA esters, a key step in fatty acid β-oxidation. By ensuring an increased availability of these molecules, HADHSC activity is indirectly enhanced, facilitating the conversion of fatty acids into acetyl-CoA. Moreover, the transport of fatty acids into mitochondria, a prerequisite for HADHSC's role, is augmented by compounds such as Carnitine and L-Carnitine, which enhance the functional capacity of HADHSC by supplying it with more substrates for β-oxidation.
Additionally, the regulatory landscape of HADHSC activity is modulated by compounds that affect the expression levels and activity of enzymes in the fatty acid oxidation pathway. Leptin, through the activation of AMP-activated protein kinase (AMPK), can lead to an upregulation of genes involved in this pathway, which likely includes HADHSC, thus indirectly promoting its activity. Other compounds like Alpha-lipoic acid and Oleoylethanolamide exert their effects by activating AMPK and PPAR-alpha, respectively, culminating in increased expression and function of HADHSC. Lastly, Coenzyme Q10, by its role in the electron transport chain, supports the β-oxidation process and thereby the activity of HADHSC.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Acetyl coenzyme A trisodium salt | 102029-73-2 | sc-210745 sc-210745A sc-210745B | 1 mg 5 mg 1 g | $46.00 $80.00 $5712.00 | 3 | |
Acetyl-CoA serves as a substrate for HADHSC in the mitochondrial matrix, where HADHSC catalyzes the oxidation of hydroxyacyl-CoA derivatives in the fatty acid oxidation cycle. This reaction is essential for the conversion of fatty acids into acetyl-CoA, leading to an enhancement of HADHSC activity. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $56.00 $186.00 $296.00 $655.00 $2550.00 $3500.00 $10500.00 | 4 | |
NAD+ is a coenzyme that is required by HADHSC for the oxidation of L-3-hydroxyacyl CoA esters, a step in the mitochondrial fatty acid β-oxidation pathway. The presence of NAD+ is crucial for this dehydrogenase activity, indirectly enhancing HADHSC function by providing necessary electron acceptors. | ||||||
L-Carnitine | 541-15-1 | sc-205727 sc-205727A sc-205727B sc-205727C | 1 g 5 g 100 g 250 g | $23.00 $33.00 $77.00 $175.00 | 3 | |
Carnitine facilitates the transport of fatty acids into mitochondria where HADHSC functions. By increasing the availability of fatty acid substrates for β-oxidation, carnitine indirectly enhances the functional activity of HADHSC. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Malonyl-CoA is involved in the regulation of fatty acid oxidation. A decrease in malonyl-CoA concentrations can relieve the inhibition of carnitine palmitoyltransferase 1 (CPT1), subsequently increasing the supply of fatty acids for β-oxidation where HADHSC is active, thereby indirectly enhancing HADHSC activity. | ||||||
Ob (hBA-147) | sc-4912 | 1000 µg | $253.00 | 1 | ||
Leptin has been found to increase fatty acid oxidation by enhancing the expression of genes involved in this pathway, including HADHSC, through activation of AMP-activated protein kinase (AMPK), indirectly leading to enhanced activity of HADHSC. | ||||||
Adenosine phosphate(Vitamin B8) | 61-19-8 | sc-278678 sc-278678A | 50 g 100 g | $160.00 $240.00 | ||
AMP accumulation can activate AMPK which in turn can enhance the oxidation of fatty acids by upregulating the expression of enzymes like HADHSC, thus indirectly enhancing HADHSC activity. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $68.00 $120.00 $208.00 $373.00 $702.00 | 3 | |
Alpha-lipoic acid can induce the upregulation of enzymes involved in mitochondrial fatty acid oxidation, such as HADHSC, by activating AMPK, indirectly enhancing HADHSC activity. | ||||||
Coenzyme Q10 | 303-98-0 | sc-205262 sc-205262A | 1 g 5 g | $70.00 $180.00 | 1 | |
Coenzyme Q10 is involved in the electron transport chain, which creates a proton gradient that indirectly supports the β-oxidation process where HADHSC is active, thus enhancing its function. | ||||||
Oleylethanolamide | 111-58-0 | sc-201400 sc-201400A | 10 mg 50 mg | $88.00 $190.00 | 1 | |
Oleoylethanolamide can enhance fatty acid oxidation by activating PPAR-alpha, which may increase the expression and activity of enzymes like HADHSC involved in this process, thereby indirectly enhancing HADHSC activity. | ||||||