GSK3 beta Antibody (1V001): sc-71186

GSK-3β Antibody (1V001) is a mouse monoclonal IgG2a that specifically detects glycogen synthase kinase 3 beta (GSK-3β) in human, rat, and Xenopus samples via western blotting (WB) and immunoprecipitation (IP). GSK-3β, also called GSK3, GSK-3, and GSK-3beta, is a serine/threonine kinase involved in key signaling pathways that regulate cellular processes such as glycogen metabolism, cell proliferation, and apoptosis. Structurally, GSK-3β has a kinase domain with an ATP-binding site and a conserved catalytic core, which is critical for function as a protein kinase. The structural configuration of GSK-3β allows phosphorylation of various substrates, and active form is tightly regulated by upstream kinases. In terms of subcellular localization, GSK-3β is found primarily in the cytoplasm but can also translocate to the nucleus and mitochondria depending on cellular context. GSK-3β′s ability to move between compartments is important for diverse functions, such as modulating glycogen synthesis in the cytoplasm or influencing gene expression in the nucleus. The spatial regulation of GSK-3β within cells is essential for precise control over cellular activities, and mislocalization has been associated with pathological conditions, including neurodegenerative diseases. By studying GSK-3β, researchers can gain insight into diverse roles in cellular function and potential contribution to disease mechanisms, making anti-GSK-3β antibody (1V001) an important tool for investigations into cellular signaling and metabolic regulation.

The preferred GSK3 alpha/beta antibody is GSK3 alpha/beta Antibody (0011-A): sc-7291.