Grx1 Antibody (3C11): sc-293250

Grx1 Antibody (3C11) is a mouse monoclonal IgG2a kappa light chain antibody that detects the Grx1 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-Grx1 antibody (3C11) is available as the non-conjugated format. Glutaredoxin (Grx1) plays a crucial role in cellular redox homeostasis, acting as a key player in thiol-disulfide exchange reactions that are vital for maintaining protein structure and function. Grx1 is primarily located in the cytoplasm, where Grx1 participates in the reduction of disulfide bonds in proteins, thereby facilitating proper protein folding and function. Grx1′s cytoplasmic localization enables rapid response to oxidative stress, protecting cells from damage by reducing oxidized proteins and maintaining redox balance. Grx1 is involved in the regulation of various signaling pathways, influencing processes such as apoptosis and cell proliferation. The unique structure of Grx1, characterized by two vicinal cysteine residues in the active site, allows effective catalysis of these critical reactions, making Grx1 an essential component in cellular defense against oxidative damage. Anti-Grx1 antibody (3C11) is a valuable tool for researchers studying oxidative stress responses, protein folding, and redox regulation in human cells.

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Grx1 Antibody (3C11) References:

1. Non-reciprocal regulation of the redox state of the glutathione-glutaredoxin and thioredoxin systems.  |  Trotter, EW. and Grant, CM. 2003. EMBO Rep. 4: 184-8. PMID: 12612609
2. Effect of glucose concentration on activation of the ASK1-SEK1-JNK1 signal transduction pathway.  |  Song, JJ. and Lee, YJ. 2003. J Cell Biochem. 89: 653-62. PMID: 12858332
3. Human mitochondrial glutaredoxin reduces S-glutathionylated proteins with high affinity accepting electrons from either glutathione or thioredoxin reductase.  |  Johansson, C., et al. 2004. J Biol Chem. 279: 7537-43. PMID: 14676218
4. Interactions of glutaredoxins, ribonucleotide reductase, and components of the DNA replication system of Escherichia coli.  |  Ortenberg, R., et al. 2004. Proc Natl Acad Sci U S A. 101: 7439-44. PMID: 15123823
5. Nuclear monothiol glutaredoxins of Saccharomyces cerevisiae can function as mitochondrial glutaredoxins.  |  Molina, MM., et al. 2004. J Biol Chem. 279: 51923-30. PMID: 15456753
6. Cloning, sequencing, and characterization of alternatively spliced glutaredoxin 1 cDNA and its genomic gene: chromosomal localization, mrna stability, and origin of pseudogenes.  |  Park, JB. and Levine, M. 2005. J Biol Chem. 280: 10427-34. PMID: 15637068
7. Glutaredoxin 1 (Grx1) Protects Human Retinal Pigment Epithelial Cells From Oxidative Damage by Preventing AKT Glutathionylation.  |  Liu, X., et al. 2015. Invest Ophthalmol Vis Sci. 56: 2821-32. PMID: 25788646
8. Salvianolic Acid B (Sal B) Protects Retinal Pigment Epithelial Cells from Oxidative Stress-Induced Cell Death by Activating Glutaredoxin 1 (Grx1).  |  Liu, X., et al. 2016. Int J Mol Sci. 17: PMID: 27827892
9. Glutaredoxin 1 (GRX1) inhibits oxidative stress and apoptosis of chondrocytes by regulating CREB/HO-1 in osteoarthritis.  |  Sun, J., et al. 2017. Mol Immunol. 90: 211-218. PMID: 28843170
10. Critical Roles of Glutaredoxin in Brain Cells-Implications for Parkinson's Disease.  |  Gorelenkova Miller, O. and Mieyal, JJ. 2019. Antioxid Redox Signal. 30: 1352-1368. PMID: 29183158
11. Glutaredoxin-1 Silencing Induces Cell Senescence via p53/p21/p16 Signaling Axis.  |  Yang, F., et al. 2018. J Proteome Res. 17: 1091-1100. PMID: 29356545
12. A Prognostic Activity of Glutaredoxin 1 Protein (Grx1) in Colon Cancer.  |  Brzozowa-Zasada, M., et al. 2024. Int J Mol Sci. 25: PMID: 38256082

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Grx1 Antibody (3C11) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-Grx1 Antibody (3C11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Grx1 Antibody (3C11) Specifications

Alternate Product Name: Grx1

Product Clone Name: 3C11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-106

Epitope Target: Grx1

Epitope Species: human

Product Reactivity/Detection: Grx1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for Grx1 Antibody (3C11): N/A