GM-CSF Antibody (1D11): sc-32805

GM-CSF Antibody (1D11) is a mouse monoclonal IgG1 antibody that detects granulocyte-macrophage colony stimulating factor (GM-CSF) in human samples through western blotting (WB) and immunoprecipitation (IP) applications. GM-CSF is a crucial pleiotropic cytokine that plays a significant role in the regulation of hematopoiesis, particularly in the proliferation and differentiation of granulocytes and macrophages. GM-CSF is synthesized as a precursor with a 17 amino acid signal peptide that is cleaved to yield a mature form consisting of 127 amino acids in humans, while the murine counterpart is slightly shorter at 124 amino acids and shares approximately 60% homology with the human version. GM-CSF extends beyond structural characteristics as a glycoprotein that not only stimulates the proliferation of hematopoietic cells but also promotes the phosphorylation of cytosolic phospholipase A2 (cPLA2) in human neutrophils, which may enhance enzyme activity and contribute to inflammatory responses. Anti-GM-CSF antibody (1D11) serves as a valuable tool for research in various diseases, including autoimmune disorders and cancer, as GM-CSF′s ability to modulate immune responses makes this protein a vital target for understanding these conditions.

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GM-CSF Antibody (1D11) References:

1. A role for G-CSF and GM-CSF in nonmyeloid cancers.  |  Aliper, AM., et al. 2014. Cancer Med. 3: 737-46. PMID: 24692240
2. Autoimmunity beyond Th17: GM-CSF producing T cells.  |  Zielinski, CE. 2014. Cell Cycle. 13: 2489-90. PMID: 25486188
3. GM-CSF: An immune modulatory cytokine that can suppress autoimmunity.  |  Bhattacharya, P., et al. 2015. Cytokine. 75: 261-71. PMID: 26113402
4. Targeting GM-CSF in rheumatoid arthritis.  |  Avci, AB., et al. 2016. Clin Exp Rheumatol. 34: 39-44. PMID: 27586802
5. GM-CSF promotes a supportive adipose and lung microenvironment in metastatic breast cancer.  |  Reggiani, F. and Bertolini, F. 2017. Oncoscience. 4: 126-127. PMID: 29142902
6. Roles of GM-CSF in the Pathogenesis of Autoimmune Diseases: An Update.  |  Lotfi, N., et al. 2019. Front Immunol. 10: 1265. PMID: 31275302
7. G-CSF and GM-CSF Are Different. Which One Is Better for COVID-19?  |  Lazarus, HM. and Gale, RP. 2021. Acta Haematol. 144: 355-359. PMID: 32791509
8. An update on GM-CSF and its potential role in melanoma management.  |  O Dillman, R. 2020. Melanoma Manag. 7: MMT49. PMID: 32922731
9. Targeting GM-CSF in inflammatory and autoimmune disorders.  |  Achuthan, AA., et al. 2021. Semin Immunol. 54: 101523. PMID: 34776300
10. GM-CSF receptor/SYK/JNK/FOXO1/CD11c signaling promotes atherosclerosis.  |  Tsukui, D., et al. 2023. iScience. 26: 107293. PMID: 37520709

The preferred GM-CSF antibody is GM-CSF Antibody (B6-2-hGMCSF): sc-32753.