FAS-L Antibody (Kay-10): sc-19988

FAS-L Antibody (Kay-10) is a mouse monoclonal IgG2b antibody that detects FAS-L in mouse samples through various applications including western blotting, immunoprecipitation, immunofluorescence, immunohistochemistry, and flow cytometry. FAS-L, or FAS ligand, plays a crucial role in the regulation of apoptosis, which is the process of programmed cell death that is essential for maintaining cellular homeostasis and immune system function. By binding to its receptor, FAS, on target cells, FAS-L initiates a cascade of events leading to cell death, thereby eliminating potentially harmful cells such as those that are virus-infected or transformed. This mechanism is vital for the immune response, as it helps to prevent the proliferation of damaged or malignant cells, thus contributing to immunological surveillance. The interaction between FAS-L and FAS is not only important for immune regulation but also has implications in various diseases, including autoimmune disorders and cancer, where dysregulation of apoptosis can lead to pathogenesis. FAS-L (Kay-10) monoclonal antibody is therefore an invaluable tool for researchers studying these critical processes in mouse models.

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FAS-L Antibody (Kay-10) References:

1. Modulation of fas-ligand (Fas-L) on human microglial cells: an in vitro study.  |  Frigerio, S., et al. 2000. J Neuroimmunol. 105: 109-14. PMID: 10742551
2. Activated human platelets express Fas-L and induce apoptosis in Fas-positive tumor cells.  |  Ahmad, R., et al. 2001. J Leukoc Biol. 69: 123-8. PMID: 11200056
3. Role of Fas/Fas-L in vascular cell apoptosis.  |  Stoneman, VE. and Bennett, MR. 2009. J Cardiovasc Pharmacol. 53: 100-8. PMID: 19188840
4. Role of the Fas/Fas-L pathway-mediated apoptosis in inflammatory heart diseases and vasculature diseases.  |  Binah, O. 2009. J Cardiovasc Pharmacol. 53: 91-3. PMID: 19188842
5. Effects of the Fas/Fas-L pathway on fluoride-induced apoptosis in SH-SY5Y cells.  |  Xu, B., et al. 2011. Environ Toxicol. 26: 86-92. PMID: 19852076
6. Expression levels of Fas/Fas-L mRNA in human brain glioma stem cells.  |  Tao, J., et al. 2012. Mol Med Rep. 5: 1202-6. PMID: 22344564
7. Pigment epithelial-derived factor (PEDF)-triggered lung cancer cell apoptosis relies on p53 protein-driven Fas ligand (Fas-L) up-regulation and Fas protein cell surface translocation.  |  Li, L., et al. 2014. J Biol Chem. 289: 30785-30799. PMID: 25225287
8. Mitochondrial- and Fas-L-mediated pathways involved in quinestrol induced spermatogenic apoptosis in adult rat testes.  |  Li, J., et al. 2014. Toxicol Mech Methods. 24: 609-15. PMID: 25258304
9. Fas-L promotes the stem cell potency of adipose-derived mesenchymal cells.  |  Solodeev, I., et al. 2018. Cell Death Dis. 9: 695. PMID: 29891848
10. Expression of proapoptotic receptors Fas/Fas-L on sperm cells and levels of their soluble forms in seminal fluid from patients with varicocele.  |  Razeghinia, MS., et al. 2022. J Reprod Immunol. 149: 103443. PMID: 34837753

The preferred FAS-L antibody is FAS-L Antibody (NOK-1): sc-19681.