Estrogen Receptor alpha Antibody (D547): sc-53490
- Estrogen Receptor alpha Antibody (D547) is a rat monoclonal IgG2a, cited in 1 publications, provided at 200 µg/ml
- raised against estrogen receptor α of human origin
- recommended for detection of Estrogen Receptor alpha of human and bovine origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Estrogen Receptor alpha Antibody (D547). This work is in progress.
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SEE ALSO...
Estrogen Receptor alpha Antibody (D547) is a rat monoclonal IgG2a raised against human Estrogen Receptor alpha (ERα), capable of detecting ERα of human and bovine origin by western blotting (WB) and immunoprecipitation (IP). ERα protein is a ligand-activated transcription factor that belongs to the steroid hormone receptor superfamily and plays a critical role in regulating gene expression involved in reproductive system development and function. Upon binding to estrogen, ERα undergoes conformational changes, dimerizes, and interacts with specific DNA sequences called estrogen response elements (EREs) to modulate the transcription of target genes associated with cell proliferation, differentiation, and apoptosis. This function is essential for normal sexual development and reproductive health, while also influencing bone density and cardiovascular health through estrogen-mediated signaling pathways. Dysregulation of ERα activity is implicated in various conditions, including osteoporosis, cardiovascular diseases, and hormone-dependent cancers like breast cancer. Understanding ERα function is important for elucidating hormonal regulation mechanisms and developing targeted therapies. Anti-ERα antibody (D547) serves as a valuable tool for researchers studying ERα′s role in physiological and pathological processes.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Estrogen Receptor alpha Antibody (D547) | sc-53490 | 200 µg/ml | $322.00 |