Cyclosporin A-d4 (CAS 59865-13-3 (unlabeled))

身体の状態 :

Solid

溶解度 :

Soluble in acetone, chloroform, ethanol, benzene, and methanol.

保存方法 :

Store at -20° C

融点 :

133-136° C

沸騰点 :

~1293.8° C at 760 mmHg (Predicted) (unlabeled)

密度 :

~1.0 g/cm³ (Predicted) (unlabeled)

屈折率 :

n²⁰_D 1.46 (Predicted) (unlabeled)

光学活性 :

α20_D -189±4, c = 0.5 in methanol (unlabeled)

IC50 :

Plasmodium falciparum: IC₅₀ = 0.47 nM; Plasmodium berghei: IC₅₀ = 1.65 nM; CyPA: IC₅₀ = 2 nM (human); CyPB: IC₅₀ = 8.78 nM (human) (unlabeled)

Ki データ :

CyPA: K_i= 2.64 nM (human); FKBP12.6: K_i= 6 nM (human); Cyclophilin 40: K_i= 7 nM (human); FKBP12: K_i= 20 nM (human) (unlabeled)

WGKドイツ :

3 (unlabeled)

RTECS :

GZ4120000

Merck 索引 :

14: 2752 (unlabeled)

MDL番号 :

MFCD00274558 (unlabeled)

Beilstein レジストリ :

3647785 (unlabeled)

SMILES :

[2H]\\C(=C/C[C@@H](C)[C@@H](O)C(N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC)C(C)C)C(=O)CCCCC)C([2H])([2H])[2H]