cyclin T1 Antibody (E-7): sc-398695
- cyclin T1 Antibody (E-7) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 2-27 at the N-terminus of cyclin T1 of human origin
- recommended for detection of cyclin T1 of mouse, rat and human origin by WB, IP, IF and ELISA
- See cyclin T1 (E-3): sc-271348 for cyclin T1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for cyclin T1 Antibody (E-7) for WB applications. These reagents are now offered in bundles with cyclin T1 Antibody (E-7) (see ordering information below).
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Cyclin T1 Antibody (E-7) is a mouse monoclonal IgG1 antibody that detects cyclin T1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Cyclin T1 plays a crucial role in transcription elongation by forming a complex with cyclin-dependent kinase 9 (Cdk9), which is essential for phosphorylating the C-terminal domain of RNA polymerase II. This phosphorylation enables RNA polymerase II to transition from transcription initiation to elongation, facilitating mRNA production. The interaction between cyclin T1 and HIV-1 Tat protein enhances Tat′s ability to bind viral TAR RNA, promoting recruitment of the cyclin T1/Cdk9 complex to RNA polymerase II. This mechanism underscores cyclin T1′s importance in normal cellular transcription processes and viral transcription, highlighting potential therapeutic intervention in HIV. Anti-cyclin T1 antibody (E-7) serves as an invaluable tool for researchers studying transcription regulation and viral interactions, providing reliable detection and characterization of cyclin T1.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
cyclin T1 Antibody (E-7) | sc-398695 | 200 µg/ml | $322.00 | |||
cyclin T1 Antibody (E-7): m-IgG Fc BP-HRP Bundle | sc-538505 | 200 µg Ab; 10 µg BP | $361.00 | |||
cyclin T1 Antibody (E-7): m-IgGκ BP-HRP Bundle | sc-536131 | 200 µg Ab; 40 µg BP | $361.00 | |||
cyclin T1 (E-7) Neutralizing Peptide | sc-398695 P | 100 µg/0.5 ml | $69.00 |